Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo.
Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo.
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目前，临床医生常规地将超声内窥镜应用于各种介入手术中，为病变器官提供治疗方案。超声内窥镜不仅能产生高分辨率的图像，而且临床使用安全，适用范围广。然而，对于软组织成像，其基于机械波的图像对比度从根本上限制了其提供生理特异性功能信息的能力。相比之下，光声内窥镜在临床相关深度具有功能性光学对比度和高空间分辨率的独特组合，是软组织成像的理想选择。光声内窥镜具有这些特性，可以克服目前超声内窥镜的局限性。此外，光声成像的好处并不以牺牲现有的超声功能为代价;光声内窥镜系统与超声成像固有地兼容，从而实现具有互补对比度的多模态成像。在这里，我们提出了同时光声和超声双模内窥镜，并证明其在体内成像内部器官的能力，说明其潜在的临床应用。
Presently, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures which provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high resolution images, it is also safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave-based image contrast fundamentally limits its ability to provide physiologically-specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically-relevant depths, ideal for soft tissue imaging. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, enabling multi-modality imaging with complementary contrast. Here, we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and demonstrate its ability to image internal organs in vivo, illustrating its potential clinical application.