Lateralization of affective processing in the insula
Lateralization of affective processing in the insula
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DOI：
10.1016/j.neuroimage.2013.04.014
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发表时间：
2013-09-01
期刊：
影响因子：
5.7
通讯作者：
Taylor, Margot J.
中科院分区：
文献类型：
--
作者：
Duerden, Emma G.;Arsalidou, Marie;Taylor, Margot J.
来自电生理和功能神经影像学研究的证据表明，强烈的偏侧化的岛叶皮层内的情感处理，然而，鲜为人知的是，这些过程在这些地区的空间位置。使用定量荟萃分析方法，使用143项功能磁共振成像研究的数据评估了以下方面的偏侧性：（1）情绪处理;（2）刺激效价（积极与消极）;（3）情绪感知与体验;（4）性别差异。对所有情绪刺激的激活发生在双侧前、中、左后丘脑。正性情绪刺激激活左前、中脊神经节，负性情绪刺激激活双侧前、中脊神经节。对情绪的感知和体验的激活在双侧前额叶最高，在中后额叶则是左侧偏侧的。在男性中，情绪刺激主要激活左前/中脊神经和右后脊神经，而女性激活双侧前脊神经和左中脊神经和后脊神经。在情绪处理及其子类别中观察到的空间差异可以全面解释岛叶皮层在情感处理中的作用，这有助于理解精神或发育障碍中的缺陷。(C)2013 Elsevier Inc. All rights reserved.
Evidence from electrophysiological and functional neuroimaging studies has suggested strong lateralization of affective processing within the insular cortices; however, little is known about the spatial location of these processes in these regions. Using quantitative meta-analytic methods the laterality of: (1) emotional processing; (2) stimulus valence (positive vs. negative); (3) perception vs. experience of emotion; and (4) sex-differences were assessed using the data from 143 functional magnetic resonance imaging studies. Activation in response to all emotional stimuli occurred in bilateral anterior and mid-insula, and the left posterior insula. Positive emotional stimuli were associated with activation in the left anterior and mid-insula, while negative emotional stimuli activated bilateral anterior and mid-insula. Activation in response to the perception and experience of emotions was highest in bilateral anterior insula, and within the mid and posterior insula it was left lateralized. In males, emotional stimuli predominantly activated the left anterior/mid-insula and right posterior insula, whereas females activated bilateral anterior insula and the left mid and posterior insula. Spatial distinctions observed in emotional processing and its subcategories can provide a comprehensive account of the role of the insular cortices in affect processing, which could aid in understanding deficits seen in psychiatric or developmental disorders. (C) 2013 Elsevier Inc. All rights reserved.