Molecular Evidence of Sexual Transmission of Ebola Virus.
Molecular Evidence of Sexual Transmission of Ebola Virus.
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DOI：
10.1056/nejmoa1509773
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发表时间：
2015-12-17
期刊：
影响因子：
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通讯作者：
Palacios G
中科院分区：
文献类型：
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作者：
Mate SE;Kugelman JR;Nyenswah TG;Ladner JT;Wiley MR;Cordier-Lassalle T;Christie A;Schroth GP;Gross SM;Davies-Wayne GJ;Shinde SA;Murugan R;Sieh SB;Badio M;Fakoli L;Taweh F;de Wit E;van Doremalen N;Munster VJ;Pettitt J;Prieto K;Humrighouse BW;Ströher U;DiClaro JW;Hensley LE;Schoepp RJ;Safronetz D;Fair J;Kuhn JH;Blackley DJ;Laney AS;Williams DE;Lo T;Gasasira A;Nichol ST;Formenty P;Kateh FN;De Cock KM;Bolay F;Sanchez-Lockhart M;Palacios G
2015 年 3 月，利比里亚发生一例疑似埃博拉病毒病 (EVD) 男性幸存者与其女性伴侣（本报告中的患者）发生性传播的病例。根据患者血液样本和幸存者精液样本组装的埃博拉病毒 (EBOV) 基因组与直接传播相符。这些基因组共有三个替换，这些替换是所有其他西非埃博拉病毒序列中所没有的，并且与该病例之前利比里亚最后记录的传播链不同。结合流行病学数据，基因组分析提供了 EBOV 性传播的证据，以及埃博拉病毒病发病后精液中感染性 EBOV 持续存在 179 天或更长时间的证据。 （由国防威胁减少局和其他机构资助。）
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.)