Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers
Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers
复制标题
DOI：
10.1021/acs.nanolett.5b04237
复制
发表时间：
2016-03-01
期刊：
影响因子：
10.8
通讯作者：
Machluf, Marcelle
中科院分区：
文献类型：
--
作者：
Kaneti, Limor;Bronshtein, Tomer;Machluf, Marcelle
来自间充质干细胞并保留其独特的表面相关肿瘤靶向能力的纳米鬼被重新设计为选择性和安全的通用非病毒基因治疗平台。在皮下和转移性原位肿瘤模型中，装载pDNA的纳米血影在体外和体内有效地靶向和转染不同的癌细胞，导致无不良反应。装载有编码癌症毒性基因的pDNA的纳米鬼抑制了转移性原位肺癌和皮下前列腺癌模型的生长，并显着延长了动物的生存期。
Nanoghosts derived from mesenchymal stem cells and retaining their unique surface-associated tumor-targeting capabilities were redesigned as a selective and safe universal nonviral gene-therapy platform. pDNA-loaded nano ghosts efficiently targeted and transfected diverse cancer cells, in vitro and in vivo, in subcutaneous and metastatic orthotopic tumor models, leading to no adverse effects. Nanoghosts loaded with pDNA encoding for a cancer-toxic gene inhibited the growth of metastatic orthotopic lung cancer and subcutaneous prostate cancer models and dramatically prolonged the animals' survival.