Significance of chromosome 5 and 17 changes in the development of carcinoma of the cervix uteri
Significance of chromosome 5 and 17 changes in the development of carcinoma of the cervix uteri
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DOI：
10.1159/000056816
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Atkin, NB
中科院分区：
文献类型：
--
作者：
Atkin, NB
两个染色体进行非随机变化的子宫颈癌，并已研究了几十年，在这个实验室进行了讨论。第一，5号染色体，讨论鉴于频繁出现的等染色体为5 p，往往在两个或更多的副本，通常与较少的预期数量的正常副本的这条染色体。第二个是17号染色体，其中涉及另一条染色体的易位可能导致17 p+，并且显著的变化似乎是17 p的丢失，其可能包括位于该染色体臂上的p53基因（TP 53）和/或其他肿瘤抑制基因。Karger AG，巴塞尔。
Two chromosomes that undergo nonrandom changes in carcinoma of the cervix and have been studied for several decades in this laboratory are discussed. The first, chromosome 5, is discussed in view of the frequent appearance of an isochromosome for 5p, often in two or more copies and commonly associated with fewer that the expected number of normal copies of this chromosome. The second is chromosome 17, where a translocation involving another chromosome may result in a 17p+, and the significant change appears to be a loss from 17p that may include the p53 gene (TP53) and/or other tumor-suppressor genes located on this chromosome arm. Copyright (C) 2001 S. Karger AG, Basel.