Changes in Brain Functional Network Connectivity in Adult Moyamoya Diseases
Changes in Brain Functional Network Connectivity in Adult Moyamoya Diseases
复制标题
DOI：
10.1007/s11571-021-09666-1
复制
发表时间：
2021-02
影响因子：
3.7
通讯作者：
Gaoxing Zheng;Y. Lei;Yuzhu Li;Wei Zhang;Jiabin Su;Xiaoying Qi;Liang Chen;Xin Zhang;Yuxiang Gu;Yuguo Yu;Y. Mao
中科院分区：
文献类型：
--
作者：
Gaoxing Zheng;Y. Lei;Yuzhu Li;Wei Zhang;Jiabin Su;Xiaoying Qi;Liang Chen;Xin Zhang;Yuxiang Gu;Yuguo Yu;Y. Mao
烟雾病（Moyamoya disease， MMD）是一种以颈内动脉及其主要分支进行性狭窄或闭塞为特征，导致异常小侧支血管形成的脑血管疾病。然而，人们对这些特殊的血管结构如何影响皮质网络连接和大脑功能知之甚少。通过对闭眼（EC）和睁眼（EO）静息状态和工作记忆（WM）任务的脑电记录进行脑电图分析和图形网络分析，研究出血性（HMMD）和缺血性MMD （imd）脑的脑网络特征。我们首次观察到，在EO状态下，imd的α阻断率比健康对照组低得多，而hmmd在所有行为状态下都表现出相对较低的脑电图活动率。此外，在EO和WM状态下，imd在额叶和顶叶区域的α波段显示出强大的网络连接。静息状态和WM状态下的脑电图频率和网络拓扑图谱显示，hmmd患者的左额叶和左顶叶以及immd患者的右顶叶和颞叶与对照组相比存在明显差异，这为了解MMD不同的电生理特征提供了新的视角。然而，由于招募的患者受试者样本量较小，结果结论可能受到限制。
Moyamoya disease (MMD) is a cerebrovascular disease that is characterized by progressive stenosis or occlusion of the internal carotid arteries and its main branches, which leads to the formation of abnormal small collateral vessels. However, little is known about how these special vascular structures affect cortical network connectivity and brain function. By applying EEG analysis and graphic network analyses undergoing EEG recording of subjects with eyes-closed (EC) and eyes-open (EO) resting states, and working memory (WM) tasks, we examined the brain network features of hemorrhagic (HMMD) and ischemic MMD (IMMD) brains. For the first time, we observed that IMMDhad the much lower alpha-blocking rate during EO state than healthy controls while HMMDexhibited the relatively low EEG activity rate across all the behavior states. Further, IMMDshowed strong network connections in the alpha-wave band in frontal and parietal regions during EO and WM states. EEG frequency and network topological maps during both resting and WM states indicated that the left frontal lobe and left parietal lobe in HMMDpatients and the right parietal lobe and temporal lobe in IMMDpatients have clear differences compared with controls, which provides a new insight to understand distinct electrophysiological features of MMD. However, due to the small sample size of recruited patient subjects, the result conclusion may be limited.