Transcriptional control by chromosome-associated protein phosphatase-1
Transcriptional control by chromosome-associated protein phosphatase-1
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DOI：
10.1042/bst0331444
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发表时间：
2005-12-01
影响因子：
3.9
通讯作者：
Bennett, D
中科院分区：
文献类型：
--
作者：
Bennett, D
基因表达的严格调控对于细胞对生理和环境信号的正常反应以及细胞特化至关重要。从组蛋白到转录机制的关键结构和调节蛋白的可逆磷酸化被认为是调节基因表达空间和时间模式的重要机制。 PP1（蛋白磷酸酶-1）是一类主要的丝氨酸/苏氨酸蛋白磷酸酶，存在于果蝇多线染色体的许多位点，参与控制基因表达和染色质结构。 PP1 通过与各种不同的调节亚基相互作用来靶向不同的染色体位点，从而改变 PH 对特定底物的活性。这篇小综述概述了已知的染色体相关 PP1 复合物、它们在转录控制中的作用以及未来分析的前景。
Tight regulation of gene expression is critical forcells to respond normally to physiological and environmental cues and to allow cell specialization. Reversible phosphorylation of key structural and regulatory proteins, from histones to the transcriptional machinery, is acknowledged to be an important mechanism of regulating spatial and temporal patterns of gene expression. PP1 (protein phosphatase-1), a major class of serine/threonine protein phosphatase, is found at many sites on Drosophila polytene chromosomes where it is involved in controlling gene expression and chromatin structure. PP1 is targeted to different chromosomal loci through interaction with a variety of different regulatory subunits, which modify PH'S activity towards specific substrates. This mini-review gives an overview of known chromosome-associated PP1 complexes, their role in transcriptional control and the prospects for future analysis.