Correct and erroneous picture naming responses in healthy subjects
Correct and erroneous picture naming responses in healthy subjects
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DOI：
10.1016/j.neulet.2009.07.077
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发表时间：
2009-10-09
影响因子：
2.5
通讯作者：
Huber, Walter
中科院分区：
文献类型：
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作者：
Abel, Stefanie;Dressel, Katharina;Huber, Walter
在这项功能性磁共振成像研究中，使用事件相关设计对 34 名健康受试者的正确和错误图片命名反应的大脑激活进行了研究。我们仅考虑包含所有 (ALL)、错误 (FAL) 或正确 (COR) 响应的主效应。尽管错误发生的情况很少见，但所有三个主要效应的激活最大值都不同。为了研究命名准确性对大脑激活的影响，我们（1）将错误数量视为协变量，（2）比较了错误率较高的受试者仔细匹配的 FAL 和 COR 集。结果，左中/内侧额回的激活与错误数量显着相关。命名错误的神经基础似乎在几个激活子系统中是分开的：首先是与监控过程相关的前扣带皮层（ACC）、前额叶和运动前区域的双侧激活；其次，右（旁）海马回的参与最有可能表明错误后的保留过程；第三周裂区（尤其是额下叶）语言区。这些激活不仅限于错误反应，而且也以较低的强度招募正确反应。相比之下，在正确的试验中，没有特定的激活来成功检索姓名。总而言之，错误命名响应和正确命名响应的底层处理机制惊人地相似。自我监控似乎是命名过程的一般机制。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
In this functional magnetic resonance imaging study, brain activations of correct and erroneous picture naming responses were investigated in 34 healthy subjects using an event-related design. We regarded main effects comprising all (ALL), false (FAL), or correct (COR) responses only. Despite the rare error occurrence, activation maxima differed between all three main effects. To investigate the influence of naming accuracy on brain activations, we therefore (1) considered the number of errors as covariates, and (2) compared carefully matched sets of FAL and COR for subjects with higher error rates. As a result, activations in left middle/medial frontal gyrus were significantly correlated with number of errors. The neural substrate of naming errors appears to be separated in several subsystems of activation: first bilateral activations in anterior cingulate cortex (ACC), prefrontal, and premotor regions associated with monitoring processes; second the involvement of right (para)hippocampal gyrus most likely indicating post-error processes of retention; third perisylvian (especially inferior frontal) language areas. These activations were not restricted to false responses, but were with less intensity also recruited for correct responses. In contrast, there was no specific activation for successful name retrieval in correct trials. To conclude, the underlying processing mechanisms of erroneous and correct naming responses are strikingly similar; self-monitoring appears to be a general mechanism of the naming process. (C) 2009 Elsevier Ireland Ltd. All rights reserved.