Influence of Dexmedetomidine on the Tourniquet Related Responses in Hypertension Patients Receiving Unilateral Knee Arthroplasty under General Anesthesia
Influence of Dexmedetomidine on the Tourniquet Related Responses in Hypertension Patients Receiving Unilateral Knee Arthroplasty under General Anesthesia
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DOI：
10.1016/j.arth.2015.02.034
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发表时间：
2015-08-01
影响因子：
3.5
通讯作者：
Tian, Mou-Li
中科院分区：
文献类型：
--
作者：
Li, Yong-Hua;Wang, Yong-Qiang;Tian, Mou-Li
本研究旨在探讨右美托咪定（DEX）对全麻下接受单侧膝关节置换术（UKA）的高血压患者止血带相关反应的影响。结果显示，无论是否有高血压，DEX组止血带诱发高血压（TIH）的发生率、血流动力学、MAC和EtSEV均显著低于对照组。而对照组和DEX组的TIH、血流动力学、最低肺泡浓度（MAC）和七氟醚呼气末浓度（EtSEV）与非高血压组比较差异无统计学意义。除高血压外，舒张后30 min内，DEX对氧合指数（OI）和呼吸指数（RI）无明显影响。总之，DEX可显著改善血流动力学，这与先前存在的高血压无关。(C)2015 Elsevier Inc. All rights reserved.
This study aimed to investigate the influence of dexmedetomidine (DEX) on the tourniquet related responses in hypertension patients receiving unilateral knee arthroplasty (UKA) under general anesthesia. Results showed that the incidence of tourniquet induced hypertension (TIH), hemodynamics, MAC and EtSEV in DEX group were significantly lower than those in control group, regardless of hypertension. However, significant differences in TIH, hemodynamics, minimum alveolar concentration (MAC) and end-tidal sevoflurane (EtSEV) were not observed between hypertension patients and non-hypertension patients in both control group and DEX group. Moreover, oxygen index (OI) and respiratory index (RI) remained unchanged after deflation and DEX failed to affect OI and RI within 30 min after deflation, regardless of hypertension. Taken together, DEX may significantly improve the hemodynamics, which is independent of pre-existing hypertension. (C) 2015 Elsevier Inc. All rights reserved.