Integrated genetic map of human chromosome 2.
Integrated genetic map of human chromosome 2.
复制标题
人类2号染色体的综合遗传图谱。
DOI：
10.1111/j.1469-1809.1995.tb00760.x
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发表时间：
1995
影响因子：
1.9
通讯作者：
Spurr,NK
中科院分区：
文献类型：
--
作者：
Cox,S;Bryant,SP;Collins,A;Weissenbach,J;Donis-Keller,H;Koeleman,BP;Steinkasserer,A;Spurr,NK
描述了人类2号染色体的框架遗传图谱，整合了来自人类多态性研究中心（CEPH）第6版数据库、CEPH 2号染色体联盟数据库、美国国立卫生研究院（NIH）/CEPH协作作图组和其他实验室的数据。一个全面的地图也提出了，显示了大量的额外的基因座的区域位置。框架图是用来确定一个信息丰富的CEPH家庭内的减数分裂断点，并讨论了利用这些信息来绘制新的标记。估计数据集中的分型错误程度，以及性别特异性干扰参数。这些遗传和额外的细胞遗传学数据的位置数据库的构建使用遗传距离映射到一个物理尺度上的算法，并检查这种方法来帮助整合遗传和物理数据的潜力。
A framework genetic map of human chromosome 2 is described, integrating data from the Centre d'Étude du Polymorphisme Humain (CEPH) version 6 database, the CEPH chromosome 2 consortium database, the National Institute of Health (NIH)/CEPH Collaborative Mapping group and other laboratories. A comprehensive map is also presented, showing regional locations of a large number of additional loci. The framework map is used to identify an informative set of meiotic breakpoints within the CEPH families, and the utility of this information for mapping new markers is discussed. The degree of typing error within the data set is estimated, as are the sex‐specific interference parameters. A location database for these genetic and additional cytogenetic data is constructed using algorithms which map genetic distances on to a physical scale, and the potential for this approach to aid the integration of genetic and physical data is examined.