Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection
Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection
复制标题
慢性乙型肝炎病毒感染患者血清 microRNA-29 水平与疾病进展相关
DOI：
10.1111/1751-2980.12185
复制
发表时间：
2014-11-01
影响因子：
3.5
通讯作者：
Li, Ning
中科院分区：
文献类型：
--
作者：
Huang, Chong;Zheng, Jian Ming;Li, Ning
目的探讨血清微小RNA-29（miR-29）作为慢性B肝炎病毒（HBV）感染患者疾病进展预测的生物标志物的作用。方法采用实时定量聚合酶链反应（PCR）技术检测慢性HBV感染患者血清miR-29 a、miR-29 b和miR-29 c水平，结果91例慢性HBV感染患者按肝纤维化分期分为S 0/1期，肝纤维化分期为S 0/1期，肝纤维化分期为S 0/1期，肝纤维化分期为S 0/1期，肝纤维化分期为S 0/1期研究中还包括S2/3（无或轻度纤维化）、S2/3（进行性纤维化）和S4（肝硬化）亚组以及12名健康个体。S 0 -3组血清miR-29 a和miR-29 c水平显著高于S4组（P0. 05）。miR-29 a-c与谷丙转氨酶水平显著相关（P
ObjectiveTo investigate the role of serum microRNA-29 (miR-29) as a biomarker for the prediction of disease progression in patients with chronic hepatitis B virus (HBV) infection.MethodsUsing real-time quantitative polymerase chain reaction assay, serum miR-29a, miR-29b and miR-29c levels were measured in patients with chronic HBV infection, and the correlation between serum miR-29 levels and the participants' liver biochemistry, fibrotic stage and necroinflammation grade were also evaluated.ResultsAltogether 91 patients with chronic HBV infection were divided by fibrotic stage into S0/1 (no or mild fibrosis), S2/3 (progressive fibrosis) and S4 (cirrhosis) subgroups, and 12 healthy individuals were also included in the study. Serum miR-29a and miR-29c in S0-3 were significantly higher than those in S4 patients (P0.05). miR-29a-c showed significant correlation with alanine transaminase levels (P