Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort
Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort
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DOI：
10.1093/humrep/deg444
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发表时间：
2003-11-01
影响因子：
6.1
通讯作者：
Baird, DD
中科院分区：
文献类型：
--
作者：
Basso, O;Baird, DD
背景：超过10%的婴儿是由怀孕10年的夫妇所生的（这是不孕症的常见定义）。一些证据表明，这样的怀孕会增加早产和其他不良分娩结果的风险，但这个问题很少在大型纵向研究中得到解决，这些研究招募了不考虑不孕治疗的夫妇。方法：我们使用来自丹麦国家出生队列的数据：55 906例单胎活产，这些妇女在妊娠中期报告了她们的等待怀孕时间（TTP）和其他协变量。结果：TTP 1年与所有研究结果的风险增加相关，包括早产[初产妇的优势比和95%置信区间为1.5(1.2,1.8)，多产妇的优势比和95%置信区间为1.9(1.5,2.4)]。调整协变量后，早产的优势比仍然升高。在TTP超过10年的夫妇中，不孕症治疗仅与多胞胎的风险增加有关。结论：不孕妇女即使未经治疗怀孕，不良分娩结果的风险也较高。由于不孕夫妇所生的婴儿占10%，因此在提供产前护理时，将这一群体视为潜在的高风险群体是很重要的。
Background: More than 10% of babies are born to couples taking >1 year to conceive (a common definition of infertility). Some evidence indicates that such pregnancies are at increased risk of preterm delivery and other adverse birth outcomes, but the problem has rarely been addressed in large, longitudinal studies enrolling couples irrespective of infertility treatment. Methods: We used data from the Danish National Birth Cohort: 55 906 singleton live births from women who reported their waiting time to pregnancy (TTP) and other covariates in an interview during the 2nd trimester of pregnancy. Results: A TTP >1 year was associated with an increased risk of all outcomes studied, including preterm birth [odds ratios and 95% confidence intervals were 1.5 (1.2, 1.8) among primiparas and 1.9 (1.5, 2.4) among multiparas]. Odds ratios for preterm remained elevated after adjustment for covariates. Among couples with a TTP >1 year, infertility treatment was associated with added risk only among multiparas. Conclusion: Infertile women are at higher risk of adverse birth outcomes even if they conceive without treatment. With >10% of babies born to infertile couples, it is important to consider this group as potentially high risk when providing prenatal care.