PATTERNS OF MEMORY FAILURE AFTER SCOPOLAMINE TREATMENT - IMPLICATIONS FOR CHOLINERGIC HYPOTHESES OF DEMENTIA
PATTERNS OF MEMORY FAILURE AFTER SCOPOLAMINE TREATMENT - IMPLICATIONS FOR CHOLINERGIC HYPOTHESES OF DEMENTIA
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DOI：
10.1016/s0163-1047(86)90772-7
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发表时间：
1986-03-01
期刊：
影响因子：
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通讯作者：
JANOWSKY, DS
中科院分区：
文献类型：
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作者：
BEATTY, WW;BUTTERS, N;JANOWSKY, DS
为了验证东莨菪碱提供了一个与皮质或皮质下痴呆相关的记忆缺陷的合适药理学模型的想法，我们评估了健康年轻正常受试者在一系列任务上的记忆力，这些受试者接受了0.5 mg东莨菪碱，0.1-0.2 mg格隆溴铵或生理盐水，在三个不同的场合各一次，并将东莨菪碱诱导的记忆障碍模式与阿尔茨海默病（AD）或亨廷顿病（HD）患者在相同任务中观察到的记忆障碍模式进行比较。与以前的报告一致，东莨菪碱损害收购和延迟召回的14个单词的列表和破坏保留布朗-彼得森分心任务，而外周活性抗胆碱能格隆溴铵没有效果。然而，在东莨菪碱的模式下，这些记忆任务的错误是完全不同的AD患者。东莨菪碱并没有增加延迟识别单词列表的假阳性错误的数量，也没有增加布朗-彼得森任务的优先项目入侵的数量。此外，东莨菪碱没有损害学习的符号数字配对联想任务，并没有减少检索的单词数量或增加重复的单词数量的标准化的口头流畅性测试。当东莨菪碱对记忆的影响进行了比较，在痴呆症患者的障碍模式与HD，几个differences被发现，虽然东莨菪碱明显产生赤字的一些措施的顺行记忆，目前的研究结果的问题是否抗胆碱能药物充分模仿全方位的记忆障碍观察到的皮质或皮质下痴呆。
To test the idea that scopolamine provides a suitable pharmacological model of the memory defects associated with cortical or subcortical dementias, we assessed memory on a battery of tasks in healthy young normal subjects who received 0.5 mg scopolamine, 0.1-0.2 mg glycopyrrolate or physiological saline, once each on three separate occasions, and compared the pattern of memory failure induced by scopolamine to that observed on the same tasks in patients with Alzheimer''s disease (AD) or Huntington''s disease (HD). In agreement with previous reports, scopolamine impaired acquisition and delayed recall of a 14-word list and disrupted retention on the Brown-Peterson distractor task, whereas the peripherally active anticholinergic glycopyrrolate was without effect. However, under scopolamine the pattern of errors made on these memory tasks was quite different from that seen in patients with AD. Scopolamine did not increase the number of false positive errors on delayed recognition of the word list and also failed to increase the number of prior-item intrusions on the Brown-Peterson task. Also, scopolamine did not impair learning of a symbol-digit paired-associate task, and did not reduce the number of words retrieved or increase the number of words repeated on a standarized verbal fluency test. When the effects of scopolamine on memory were compared to the pattern of impairments observed in demented patients with HD, several differences were found. Although scopolamine clearly produces deficits on some measures of anterograde memory, the present findings question whether anticholinergic drugs adequately mimic the full range of memory impairments observed in cortical or subcortical dementias.