D-lactic acidosis in humans: review of update.
D-lactic acidosis in humans: review of update.
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DOI：
10.5049/ebp.2006.4.1.53
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
Kang, Sung Kyew
中科院分区：
文献类型：
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作者：
Kang, Kyung Pyo;Lee, Sik;Kang, Sung Kyew
D-乳酸酸中毒在反刍动物中已有充分记录。在人类中，D-乳酸性酸中毒非常罕见，但 D-乳酸性酸中毒可能比一般认为的更为常见，在酸中毒原因不明显的代谢性酸中毒病例中应进行检查。 D-乳酸性酸中毒的临床表现以脑病和代谢性酸中毒发作为特征。该实体应被视为代谢性酸中毒患者的诊断，伴有高阴离子间隙、正常乳酸水平、阴性 Acetest、短肠综合征或吸收不良病史以及特征性神经系统表现。低碳水化合物饮食、碳酸氢盐治疗、补液和口服抗生素将有助于控制症状。
D-Lactic acidosis has been well documented in ruminants. In humans, D-lactic acidosis is very rare, but D-lactic acidosis may be more common than generally believed and should be looked for in a case of metabolic acidosis in which the cause of acidosis is not apparent. The clinical presentation of D-lactic acidosis is characterized by episodes of encephalopathy and metabolic acidosis. The entity should be considered as a diagnosis in a patient who presents with metabolic acidosis accompanied by high anion gap, normal lactate level, negative Acetest, history of short bowel syndrome or malabsorption, and characteristic neurologic manifestations. Low carbohydrate diet, bicarbonate treatment, rehydration, and oral antibiotics would be helpful in controlling symptoms.