Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long-acting beta agonists.
Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long-acting beta agonists.
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DOI：
10.1002/ajim.23272
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发表时间：
2021-10
影响因子：
3.5
通讯作者：
Weiden, Michael D.
中科院分区：
文献类型：
--
作者：
Goldfarb, David G.;Putman, Barbara;Lahousse, Lies;Zeig-Owens, Rachel;Vaeth, Brandon M.;Schwartz, Theresa;Hall, Charles B.;Prezant, David J.;Weiden, Michael D.
在世贸中心（WTC）暴露的消防员中，大于一秒用力呼气量（FEV 1）的平均损失是哮喘、慢性阻塞性肺疾病（COPD）和哮喘/COPD重叠综合征的危险因素。吸入性皮质类固醇和长效β受体激动剂（ICS/LABA）用于治疗阻塞性气道疾病，但其对该人群FEV 1轨迹的影响尚不清楚。研究人群包括暴露于WTC的男性消防员，他们接受ICS/LABA治疗2年或更长时间（2015年之前开始），在ICS/LABA开始前至少有两次FEV 1测量值，在2001年9月11日至2019年9月10日期间治疗后至少有两次FEV 1测量值。使用线性混合效应模型估计治疗前和治疗后FEV 1斜率。在随访期间，1023名WTC暴露的消防员接受了ICS/LABA治疗2年或更长时间。当比较治疗前6年和治疗后6年的时间间隔时，受试者在校正基线FEV 1、种族、身高、WTC暴露、体重变化、血嗜酸性粒细胞浓度和吸烟状态后，FEV 1斜率改善18.7 ml/年（95%置信区间[CI]：11.3-26.1）。按ICS/LABA开始的中位日期（2010年1月14日）分层后，早期ICS/LABA-开始者的斜率改善为32.5 ml/年（95% CI：19.5-45.5），但晚期ICS/LABA-开始者的FEV 1-斜率改善不显著（7.9 ml/年，95% CI：-0.5至17.2）。接受ICS/LABA治疗的暴露于WTC的消防员在开始后改善了FEV 1斜率，特别是那些开始较早的消防员。但是，如果在中位开始日期（2010年1月14日）之后开始治疗，则治疗与FEV 1斜率改善无关，这可能是因为疾病在治疗开始之前开始发作。需要对ICS/LABA治疗无效且FEV 1下降幅度大于平均值的患者进行替代治疗研究。
Greater than average loss of one‐second forced expiratory volume (FEV1) is a risk factor for asthma, chronic obstructive pulmonary disease (COPD), and asthma/COPD overlap syndrome in World Trade Center (WTC)‐exposed firefighters. Inhaled corticosteroids and long‐acting beta agonists (ICS/LABA) are used to treat obstructive airways disease but their impact on FEV1‐trajectory in this population is unknown. The study population included WTC‐exposed male firefighters who were treated with ICS/LABA for 2 years or longer (with initiation before 2015), had at least two FEV1 measurements before ICS/LABA initiation and two FEV1 measurements posttreatment between September 11, 2001 and September 10, 2019. Linear mixed‐effects models were used to estimate FEV1‐slope pre‐ and post‐treatment. During follow‐up, 1023 WTC‐exposed firefighters were treated with ICS/LABA for 2 years or longer. When comparing intervals 6 years before and 6 years after treatment, participants had an 18.7 ml/year (95% confidence interval [CI]: 11.3–26.1) improvement in FEV1‐slope after adjustment for baseline FEV1, race, height, WTC exposure, weight change, blood eosinophil concentration, and smoking status. After stratification by median date of ICS/LABA initiation (January 14, 2010), earlier ICS/LABA‐initiators had a 32.5 ml/year (95% CI: 19.5–45.5) improvement in slope but later ICS/LABA‐initiators had a nonsignificant FEV1‐slope improvement (7.9 ml/year, 95% CI: −0.5 to 17.2). WTC‐exposed firefighters treated with ICS/LABA had improved FEV1 slope after initiation, particularly among those who started earlier. Treatment was, however, not associated with FEV1‐slope improvement if started after the median initiation date (1/14/2010), likely because onset of disease began before treatment initiation. Research on alternative treatments is needed for patients with greater than average FEV1‐decline who have not responded to ICS/LABA.
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影响因子：
9.6
作者：
Weiden, Michael D.;Ferrier, Natalia;Prezant, David J.
通讯作者：
Prezant, David J.
DOI：
10.3109/02770903.2012.743149
发表时间：
2013-02
期刊：
The Journal of asthma : official journal of the Association for the Care of Asthma
影响因子：
--
作者：
Kazeros A;Maa MT;Patrawalla P;Liu M;Shao Y;Qian M;Turetz M;Parsia S;Caplan-Shaw C;Berger KI;Goldring R;Rogers L;Reibman J
通讯作者：
Reibman J
DOI：
10.3390/ijerph17239056
发表时间：
2020-12-04
影响因子：
--
作者：
Putman B;Lahousse L;Goldfarb DG;Zeig-Owens R;Schwartz T;Singh A;Vaeth B;Hall CB;Lancet EA;Webber MP;Cohen HW;Prezant DJ;Weiden MD
通讯作者：
Weiden MD
影响因子：
4.9
作者：
Vossbrinck, Madeline;Zeig-Owens, Rachel;Prezant, David J.
通讯作者：
Prezant, David J.
影响因子：
24.3
作者：
Miller, MR;Hankinson, J;Wanger, J
通讯作者：
Wanger, J