The Impact of Sex Differences on Fractional Flow Reserve-Guided Percutaneous Coronary Intervention A FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) Substudy
The Impact of Sex Differences on Fractional Flow Reserve-Guided Percutaneous Coronary Intervention A FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) Substudy
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DOI：
10.1016/j.jcin.2012.06.016
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发表时间：
2012-10-01
影响因子：
11.3
通讯作者：
Fearon, William F.
中科院分区：
文献类型：
--
作者：
Kim, Hyun-Sook;Tonino, Pim A. L.;Fearon, William F.
目的本研究旨在评估性别差异对血流储备分数（FFR）引导的经皮冠状动脉介入治疗（PCI）的影响。背景FAME（血流储备分数与血管造影多支血管评价）研究表明，与血管造影引导的策略相比，血流储备分数引导的PCI可改善结局。FFR引导的PCI在女性与男性中的作用尚未评估。方法我们分析了FAME研究中744名男性和261名女性多支冠状动脉疾病患者的2年数据，这些患者被随机分配到血管造影或FFR引导的PCI组。根据性别进行统计学比较分层治疗methods.Results虽然女性年龄较大，有显着较高的高血压率比男性，有没有差异的主要不良心脏事件的发生率（20.3%比20.2%，p = 0.923），其个别组成部分在2年。女性的FFR值显著高于男性（0.75 +/- 0.18 vs. 0.71 +/- 0.17，p = 0.001）。功能显著病变（FFR）的比例
Objectives This study sought to evaluate the impact of sex differences on fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI).Background The FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study demonstrated that FFR-guided PCI improves outcomes compared with an angiography-guided strategy. The role of FFR-guided PCI in women versus men has not been evaluated.Methods We analyzed 2-year data from the FAME study in the 744 men and 261 women with multivessel coronary disease, who were randomized to angiography- or FFR-guided PCI. Statistical comparisons based on sex were stratified by treatment method.Results Although women were older and had significantly higher rates of hypertension than men did, there were no differences in the rates of major adverse cardiac events (20.3% vs. 20.2%, p = 0.923) and its individual components at 2 years. FFR values were significantly higher in women than in men (0.75 +/- 0.18 vs. 0.71 +/- 0.17, p = 0.001). The proportion of functionally significant lesions (FFR