Variations in maternal care in infancy regulate the development of stress reactivity
Variations in maternal care in infancy regulate the development of stress reactivity
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DOI：
10.1016/s0006-3223(00)01084-2
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发表时间：
2000-12-15
影响因子：
10.6
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Caldji, C;Diorio, J;Meaney, MJ
出生后早期自然发生的母婴护理差异与大鼠对应激的行为和下丘脑-垂体-肾上腺反应的个体差异的发展有关。这些效应似乎是由母亲舔/梳理的影响和中枢系统的发展所介导的，中枢系统通过对前脑去甲肾上腺素系统的影响来激活(促肾上腺皮质激素释放因子)或抑制(伽马氨基丁酸)对压力的行为和内分泌反应的表达，重要的是，母亲护理中的个体差异从母亲传递给女儿，为个体在应激反应中的不同世代之间的行为传递提供了一种机制，(C)2000生物精神病学学会。
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking/grooming an the development of central systems that serve to activate (corticotropin-releasing factor) or inhibit (gamma -aminobutyric acid) the expression of behavioral and endocrine responses to stress through effects on forebrain noradrenergic systems, Importantly, individual differences in maternal care are transmitted from mother to daughter, providing a mechanism for the behavioral transmission of individual differences in stress reactivity across generations, (C) 2000 Society of Biological Psychiatry.