Synthesis of (-)-Hygromycin A: Application of Mitsunobu Glycosylation and Tethered Aminohydroxylation
Synthesis of (-)-Hygromycin A: Application of Mitsunobu Glycosylation and Tethered Aminohydroxylation
复制标题
DOI：
10.1002/anie.200902840
复制
发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Churruca, Fatima
中科院分区：
文献类型：
--
作者：
Donohoe, Timothy J.;Flores, Aida;Churruca, Fatima
合成（-）-潮霉素A的关键点是用于制备氨基环醇单元的栓系氨羟基化反应和糖单元上的大体积保护基的选择，以促进选择性Mitsunobu糖基化，并赋予否则易受伤害的质子动力学稳定性。© 2009 Wiley-VCH Verlag GmbH and Co. KCaA.
Key points in the synthesis of (-)-hygromycin A are the tethered aminohydroxylation reaction used to prepare the aminocyclitol unit and the choice of a bulky protecting group on the sugar unit to facilitate selective Mitsunobu glycosylation and also bestow kinetic stability upon an otherwise vulnerable proton. © 2009 Wiley-VCH Verlag GmbH and Co. KCaA.