Does contemporary oxygenator design influence haemolysis?
Does contemporary oxygenator design influence haemolysis?
复制标题
现代氧合器设计会影响溶血吗？
DOI：
10.1177/0267659113483803
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
F. de Somer
中科院分区：
文献类型：
--
作者：
F. de Somer
基于它们的设计，所有膜式氧合器都会产生一定的流动阻力。在临床实践中，这种阻力是通过测量血流量和氧合器上的压降来计算的。历史上，一些设计，如Kolobow螺旋线圈氧合器和Cobe平板氧合器，有相当高的压降，但是，尽管如此，被认为是非常适合血液的。今天，中低压降氧合器都是市售的。基于物理学和现有文献，本综述旨在探讨压降本身是否可以被认为是溶血的独立因素。
Based on their design, all membrane oxygenators generate a certain resistance to flow. In clinical practice, this resistance is calculated by measuring both blood flow and the pressure drop over the oxygenator. Historically, some designs, such as the Kolobow spiral coil oxygenator and the Cobe flat sheet oxygenator, had quite a high pressure drop, but were, nevertheless, considered very haemocompatible. Today, both medium and low pressure drop oxygenators are commercially available. Based on physics and the existing literature, this review aims to investigate whether pressure drop by itself can be considered an independent factor of haemolysis.