Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity
Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity
复制标题
DOI：
10.1038/s41598-018-35834-1
复制
发表时间：
2018-12-04
影响因子：
4.6
通讯作者：
Horstmann, Annette
中科院分区：
文献类型：
--
作者：
Morys, Filip;Bode, Stefan;Horstmann, Annette
与瘦人相比，肥胖者对未来奖励的折扣程度更高，这通常被认为是不利的。此外，他们的决定更容易被与决策无关的线索改变。在这里，我们使用功能性 MRI 研究了这种现象的神经相关性。我们在启动延迟折扣范式上测试了 30 名瘦人和 26 名肥胖人类受试者，使用正价、中性价和负价的味觉和视觉线索来偏向他们的跨期偏好。我们假设奖励相关区域和行为控制区域的激活差异以及这些区域之间连接的变化将反映这些线索的效果。在这里，与瘦人相比，肥胖者更容易受到负面味觉暗示的影响，导致延迟选择。这与启动期间左背外侧前额叶皮层的较低活动有关。行为启动效应对 dlPFC 和腹内侧 PFC 之间功能连接的调节与 BMI 呈负相关。这可能表明肥胖个体的默认目标与瘦参与者的默认目标不同，因为 dlPFC 被认为参与内部目标追求。目前的结果进一步加深了我们对 PFC 在决策中的作用的理解，并可能为未来基于非侵入性脑刺激的体重管理方法提供信息。
Obese individuals discount future rewards to a higher degree than lean individuals, which is generally considered disadvantageous. Moreover, their decisions are altered more easily by decision-irrelevant cues. Here, we investigated neural correlates of this phenomenon using functional MRI. We tested 30 lean and 26 obese human subjects on a primed delay discounting paradigm using gustatory and visual cues of positive, neutral and negative valence to bias their intertemporal preferences. We hypothesised that activation differences in reward-related and behavioural control areas, and changes in connectivity between these areas, would reflect the effect of these cues. Here, obese subjects were more susceptible to priming with negative gustatory cues towards delayed choices as opposed to lean subjects. This was related to lower activity in the left dorsolateral prefrontal cortex during priming. Modulation of functional connectivity between the dlPFC and the ventromedial PFC by the behavioural priming effect correlated negatively with BMI. This might indicate that default goals of obese individuals were different from those of lean participants, as the dlPFC has been suggested to be involved in internal goal pursuit. The present results further our understanding of the role of the PFC in decision-making and might inform future weight-management approaches based on non-invasive brain stimulation.