Flax oil-mediated activation of PPAR-γ correlates with reduction of hepatic lipid accumulation in obese spontaneously hypertensive/NDmcr-cp rats, a model of the metabolic syndrome
Flax oil-mediated activation of PPAR-γ correlates with reduction of hepatic lipid accumulation in obese spontaneously hypertensive/NDmcr-cp rats, a model of the metabolic syndrome
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DOI：
10.1017/s0007114510002187
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发表时间：
2010-11-01
影响因子：
3.6
通讯作者：
Cheema, Sukhinder K.
中科院分区：
文献类型：
--
作者：
Chechi, Kanta;Yasui, Naomi;Cheema, Sukhinder K.
由于亚麻油的n-3脂肪酸含量高，亚麻油喂养已被提出对代谢综合征的结果有有益的影响;然而，其作用机制在很大程度上仍然未知。我们研究了亚麻油喂养对自发性高血压（SHR）/NDmcr-cp大鼠（代谢综合征的遗传模型）的高脂血症、高血脂、肝脂肪变性和氧化应激的影响。还评估了PPAR-alpha、PPAR-gamma和固醇调节元件结合蛋白-1c的肝脏基因表达，以研究可能的潜在机制。肥胖和瘦SHR/NDmcr-cp大鼠喂食富含猪油或亚麻油的高脂饮食4周。肥胖大鼠的体重、肝脏重量、肠系膜脂肪垫、附睾脂肪垫和肾脏脂肪垫重量、血清中TAG和胆固醇浓度以及VLDL、LDL和HDL组分均高于瘦大鼠（P
Flax oil feeding has been proposed to have beneficial effects on the outcome of the metabolic syndrome due to the high n-3 fatty acid content of flax oil; however, the mechanisms of its action remain largely unknown. We investigated the effects of flax oil feeding on hyperlipidaemia, hyperglycaemia, hepatic steatosis and oxidative stress in the spontaneously hypertensive (SHR)/NDmcr-cp rats, a genetic model of the metabolic syndrome. Hepatic gene expression of PPAR-alpha, PPAR-gamma and sterol-regulatory element-binding protein-1c was also assessed in order to investigate the possible underlying mechanisms. Obese and lean SHR/NDmcr-cp rats were fed high-fat diets enriched with either lard or flax oil for a period of 4 weeks. Obese rats exhibited higher body weight, liver weight and mesenteric fat-, epididymal fat-and renal fat-pad weights, and also TAG and cholesterol concentrations in serum and VLDL, LDL and HDL fractions, when compared with the lean rats (P