GROWTH INUTERO, BLOOD-PRESSURE IN CHILDHOOD AND ADULT LIFE, AND MORTALITY FROM CARDIOVASCULAR-DISEASE
GROWTH INUTERO, BLOOD-PRESSURE IN CHILDHOOD AND ADULT LIFE, AND MORTALITY FROM CARDIOVASCULAR-DISEASE
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DOI：
10.1136/bmj.298.6673.564
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发表时间：
1989-03-04
影响因子：
105.7
通讯作者：
WADSWORTH, MEJ
中科院分区：
文献类型：
--
作者：
BARKER, DJP;OSMOND, C;WADSWORTH, MEJ
在英国 9921 名 10 岁儿童和 3259 名成年人的全国样本中，收缩压与出生体重呈负相关。该关联与胎龄无关，因此可能归因于胎儿生长减少。这表明宫内环境影响成年后的血压。进一步的证据表明，英国平均血压和心血管疾病死亡率的地理差异部分反映了过去宫内环境的差异。在英格兰和威尔士，生活在心血管死亡率高地区的 10 岁儿童比生活在其他地区的人更矮，静息脉搏率也更高。他们的母亲也更矮，舒张压也更高。这表明童年环境中存在持续的地理差异，导致心血管死亡率存在差异。
In national samples of 9921 10 year olds and 3259 adults in Britian systolic blood pressure was inversely related to birth weight. The association was independent of gestational age and may therefore be attributed to reduced fetal growth. This suggests that the intrauterine environment influences blood pressure during adult life. It is further evidence that the geographical differences in average blood pressure and mortality from cardiovascular disease in Britian partly reflect past differences in the intrauterine environment. Within England and Wales 10 year olds living in areas with high cardiovascular mortality were shorter and had higher resting pulse rates than those living in other areas. Their mothers were also shorter and had higher diastolic blood pressures. This suggests that there are persisting geographical differences in the childhood environment that predispose to differences in cardiovascular mortality.