Phenylbiguanide not phenyldiguanide is used to evoke the pulmonary chemoreflex in anaesthetized rabbits
Phenylbiguanide not phenyldiguanide is used to evoke the pulmonary chemoreflex in anaesthetized rabbits
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苯双胍而非苯双胍用于诱发麻醉兔子的肺化学反射
DOI：
10.1113/expphysiol.1990.sp003413
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发表时间：
1990
影响因子：
2.7
通讯作者：
Dj Armstrong
中科院分区：
文献类型：
--
作者：
I. Kay;Dj Armstrong
在戊巴比妥麻醉的兔中研究了苯双胍（PBG）、苯双胍（PDG）、苯胍（PG）和5-羟色胺（5-HT）诱发的肺化学反射。效价的等级顺序为5-HT大于PBG大于PG大于PDG。所有激动剂诱发的反应均被选择性5-HT 3受体拮抗剂MDL 72222预处理所拮抗，表明其反射效应由位于肺迷走神经传入纤维上的5-HT 3受体介导。此外，考虑到与PBG相比PDG的低效力和长的注射反应时间，我们得出结论，以前的工作者使用PBG而不是PDG来识别无髓鞘肺迷走神经传入和诱发肺化学反射。
The pulmonary chemoreflexes evoked by phenylbiguanide (PBG), phenyldiguanide (PDG), phenylguanidine (PG) and 5‐hydroxytryptamine (5‐HT) have been investigated in the pentobarbitone‐anaesthetized rabbit. The rank order of potency was 5‐HT greater than PBG greater than PG greater than PDG. The responses evoked by all agonists were antagonized by pre‐treatment with the selective 5‐HT3 receptor antagonist MDL 72222, suggesting that their reflex effects are mediated by 5‐HT3 receptors located on pulmonary vagal afferents. Furthermore, considering the low potency and long injection response time of PDG compared to PBG, we conclude that previous workers have used PBG and not PDG to identify non‐myelinated pulmonary vagal afferents and to evoke the pulmonary chemoreflex.