Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): Mechanical, setting properties, bioactivity and cytotoxicity in vitro
Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): Mechanical, setting properties, bioactivity and cytotoxicity in vitro
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DOI：
10.1002/pc.22600
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发表时间：
2013-11
影响因子：
5.2
通讯作者：
M. L. Hernández;Lizette Morejón Alonso;M. M. Pradas-M.;O. Lozano;Dainelys Guadarrama Bello
中科院分区：
文献类型：
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作者：
M. L. Hernández;Lizette Morejón Alonso;M. M. Pradas-M.;O. Lozano;Dainelys Guadarrama Bello
制备了聚甲基丙烯酸甲酯与硅烷化羟基磷灰石（HA）微纳米粒子的新型复合材料。Coralina® HA是MicroHA填料，合成NanoHA是增强材料。总无机物含量和微米与纳米HA的比例对凝固性能的影响（即，固化时间和峰值聚合温度）、压缩强度和在模拟体液（SBF）中的体外生物活性。新型复合材料表现出适当的处理性能。抗压强度范围为71.30 ± 0.04和80.0 ± 2.4 MPa。峰值聚合温度在44.5 ± 0.5至50.8 ± 1.8°C之间变化，因此符合ISO 5833标准。复合材料在SBF中表现出良好的磷酸钙沉积，无机物含量为30wt%的复合材料对L929成纤维细胞无细胞毒性。这些结果鼓励进一步测试这些新型复合材料在人类健康应用中的潜在未来用途。Polym. COMPOS.，34：1927-1937，2013.© 2013年塑料工程师协会
Novel composites of poly(methyl methacrylate) with silanized micro and nanohydroxyapatite (HA) particles were prepared. Coralina® HA was the MicroHA filler and synthetic NanoHA was the reinforcement. The influence of the total inorganic content and the proportion of micro- to NanoHA on the setting properties (i.e., setting time and peak polymerization temperature), compressive strength, and in vitro bioactivity in simulated body fluid (SBF) was analyzed. The novel composites exhibited appropriate handling properties. Compressive strength ranged between 71.30 ± 0.04 and 80.0 ± 2.4 MPa. The peak polymerization temperatures varied from 44.5 ± 0.5 to 50.8 ± 1.8°C, and thus complying with the ISO 5833 standard. The composites exhibited excellent calcium phosphate deposition in SBF and those with 30 wt% inorganic content showed no cytotoxicity on L929 fibroblastic cells. These results encourage further testing of these novel composites for potential future use in human health applications. POLYM. COMPOS., 34:1927–1937, 2013. © 2013 Society of Plastics Engineers