Enantioselective construction of the tricyclic core of curcusones A–D via a cross-electrophile coupling approach
Enantioselective construction of the tricyclic core of curcusones A–D via a cross-electrophile coupling approach
复制标题
通过交叉亲电子偶联方法对映体选择性构建 Curcusone A–D 的三环核心
DOI：
10.1039/c9sc04127c
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发表时间：
2019
期刊：
影响因子：
8.4
通讯作者：
Stoltz, Brian M.
中科院分区：
文献类型：
--
作者：
Wright, Austin C.;Stoltz, Brian M.
本文报道了利用互补Stetter环化或闭合复分解（RCM）方法对二萜类天然产物库库酮A-D进行对映选择性全合成的最新进展。使用后一种方法，我们已经实现了嵌入在curcusone家族每个成员中的5-7-6碳环核的简洁构建。这条路线的关键是使用交叉亲电偶联策略，这在天然产物合成的背景下以前没有被利用。
Herein we report our recent progress toward the enantioselective total synthesis of the diterpenoid natural products curcusones A–D by means of complementary Stetter annulation or ring-closing metathesis (RCM) disconnections. Using the latter approach, we have achieved the concise construction of the 5–7–6 carbocyclic core embedded in each member of the curcusone family. Essential to this route is the use of a cross-electrophile coupling strategy, which has not previously been harnessed in the context of natural product synthesis.