Atypical development of white matter microstructure in adolescents with autism spectrum disorders
Atypical development of white matter microstructure in adolescents with autism spectrum disorders
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DOI：
10.1016/j.neuroimage.2010.01.011
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发表时间：
2010-04-15
期刊：
影响因子：
5.7
通讯作者：
Lin, Ching-Po
中科院分区：
文献类型：
--
作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
自闭症谱系障碍（ASD）青少年的扩散张量成像（DTI）研究表明，异常的额叶白色物质（WM）的神经发育，潜在的ASD异常的社会认知和沟通。在这里，我们进一步使用基于轨迹的空间统计（TBSS）来检查WM骨骼的发育变化（即，最紧凑的全脑WM）在青春期的ASD。全脑DTI采用TBSS测量了50名青少年、25名ASD和25名对照组的各向异性分数（FA）以及纵向和径向弥散度。结果显示，与对照组相比，ASD青少年内囊右后肢FA显著降低（远端径向扩散率增加，中央纵向扩散率降低）。与对照组相比，ASD青少年（年龄和智商协变）在额叶（径向扩散率降低）、右侧扣带回（径向扩散率降低）、双侧颞叶（径向扩散率降低和纵向扩散率增加）、右侧上级颞回（径向扩散率降低）和双侧小脑中脚（径向扩散率降低）的FA显著更高。值得注意的是，在右侧中央旁小叶和双侧上级额回中发现了与年龄相关的显著相互作用，如对照组中与年龄相关的FA增加，而ASD中与年龄相关的FA减少所示。据我们所知，这是第一个使用TBSS来检查ASD患者WM的研究。我们的研究结果表明，额叶表现出异常的WM微观结构以及异常的神经发育在青春期的ASD。支持自闭症的额叶分离理论(C)2010年爱思唯尔公司All rights reserved.
Diffusion tensor imaging (DTI) studies in adolescents with autism spectrum disorders (ASD) indicate aberrant neurodevelopment of frontal white matter (WM), potentially underlying abnormal social cognition and communication in ASD. Here, we further use tract-based spatial statistics (TBSS) to examine the developmental change of WM skeleton (i.e., the most compact whole-brain WM) during adolescence in ASD. This whole-brain DTI used TBSS measures fractional anisotropy (FA) and longitudinal and radial diffusivities in fifty adolescents, 25 ASD and 25 controls. Results show that adolescents with ASD versus controls had significantly reduced FA in the right posterior limb of internal capsule (increased radial diffusivity distally and reduced longitudinal diffusivity centrally). Adolescents with ASD versus controls (covarying for age and IQ) had significantly greater FA in the frontal lobe (reduced radial diffusivity), right cingulate gyrus (reduced radial diffusivity), bilateral insula (reduced radial diffusivity and increased longitudinal diffusivity), right superior temporal gyrus (reduced radial diffusivity), and bilateral middle cerebellar peduncle (reduced radial diffusivity). Notably, a significant interaction with age by group Was found in the right paracentral lobule and bilateral superior frontal gyrus as indicated by an age-related FA gain in the controls whilst an age-related FA loss in the ASD. To our knowledge, this is the first Study to use TBSS to examine WM in individuals with ASD. Our findings indicate that the frontal lobe exhibits abnormal WM microstructure as well as an aberrant neurodevelopment during adolescence in ASD. which support the frontal disconnectivity theory of autism. (C) 2010 Elsevier Inc. All rights reserved.