Methamphetamine-associated pulmonary arterial hypertension: data from the national biological sample and data repository for pulmonary arterial hypertension (PAH Biobank).
Methamphetamine-associated pulmonary arterial hypertension: data from the national biological sample and data repository for pulmonary arterial hypertension (PAH Biobank).
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DOI：
10.1136/bmjresp-2023-001917
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发表时间：
2023-12-07
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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本研究比较了甲基苯丙胺相关性肺动脉高压（MA-PAH）与特发性肺动脉高压（IPAH）和结缔组织相关性肺动脉高压（CTD-PAH）的临床和血流动力学严重程度。它还检查了MA-PAH患者的临床和生理参数的性别差异。这是一项横断面研究，使用来自美国国家肺动脉高压生物样本和数据库（PAH生物库）的临床数据，比较男性和女性MA-PAH患者的临床和生理特征。该分析包括1830名入组PAH生物库的患者，诊断为MA-PAH （n=42）、IPAH （n=1073）或CTD-PAH （n=715）。本研究评估并比较了MA-PAH、IPAH和CTD-PAH患者的临床和血流动力学参数。在分析的患者中，42例患有MA-PAH，其中69.1%为女性。MA-PAH、IPAH和CTD-PAH患者的功能分级差异无统计学意义。预测6分钟步行距离（6MWD）的百分比在三组之间是相似的。MA-PAH患者的平均肺动脉压和肺血管阻力与IPAH患者相似，但高于CTD-PAH患者。男性MA-PAH患者表现出较差的功能等级和较低的预测6MWD，但在血流动力学结果中没有观察到性别之间的显著差异。MA-PAH和IPAH在血流动力学上没有差异，但我们发现MA-PAH与CTD-PAH不同。该研究没有发现MA-PAH存在性别差异的证据。需要进一步研究以确定MA-PAH的危险因素和潜在机制，特别是考虑到甲基苯丙胺使用的日益流行。这些调查将有助于制定有效的预防和治疗策略。
This study compares the clinical and haemodynamic severity of methamphetamine-associated pulmonary arterial hypertension (MA-PAH) with idiopathic pulmonary arterial hypertension (IPAH) and connective tissue-associated pulmonary arterial hypertension (CTD-PAH). It also examines sex differences in clinical and physiological parameters among those with MA-PAH. This is a cross-sectional study using clinically derived data from the National Biological Sample and Data Repository for Pulmonary Arterial Hypertension (PAH biobank), a US-based registry, to compare clinical and physiological characteristics between males and females with MA-PAH. The analysis included 1830 patients enrolled in the PAH biobank, with a diagnosis of MA-PAH (n=42), IPAH (n=1073), or CTD-PAH (n=715). The study assessed and compared the clinical and haemodynamic parameters of patients with MA-PAH, IPAH and CTD-PAH. Among the patients analysed, 42 had MA-PAH, with 69.1% being female. There were no statistically significant differences in functional class among patients with MA-PAH, IPAH and CTD-PAH. The per cent predicted 6-min walk distance (6MWD) was comparable between the three groups. Patients with MA-PAH had similar mean pulmonary artery pressure and pulmonary vascular resistance to patients with IPAH but higher compared with patients with CTD-PAH. Male patients with MA-PAH exhibited a worse functional class and lower per cent predicted 6MWD, but no significant differences in haemodynamic findings were observed between the sexes. There were no differences in haemodynamic between MA-PAH and IPAH but we found that MA-PAH differed from CTD-PAH. The study did not find evidence of sex differences in MA-PAH. Further research is necessary to identify risk factors and underlying mechanisms of MA-PAH, particularly considering the increasing prevalence of methamphetamine use. Such investigations will contribute to the development of effective prevention and treatment strategies for this condition.
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DOI：
10.1196/annals.1432.042
发表时间：
2008-01-01
期刊：
DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES
影响因子：
--
作者：
Rothman, Richard B.;Zolkowska, Dorota;Baumann, Michael H.
通讯作者：
Baumann, Michael H.
DOI：
10.1183/13993003.04229-2020
发表时间：
2021-07
期刊：
The European respiratory journal
影响因子：
--
作者：
Montani D;Girerd B;Jaïs X;Laveneziana P;Lau EMT;Bouchachi A;Hascoët S;Günther S;Godinas L;Parent F;Guignabert C;Beurnier A;Chemla D;Hervé P;Eyries M;Soubrier F;Simonneau G;Sitbon O;Savale L;Humbert M
通讯作者：
Humbert M
影响因子：
3.9
作者：
Hser, YI;Evans, E;Huang, YC
通讯作者：
Huang, YC
影响因子：
24.3
作者：
Humbert, M;Deng, Z;Morse, JH
通讯作者：
Morse, JH
DOI：
10.1161/circep.121.010273
发表时间：
2022-01
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
Dominic P;Ahmad J;Awwab H;Bhuiyan MS;Kevil CG;Goeders NE;Murnane KS;Patterson JC;Sandau KE;Gopinathannair R;Olshansky B
通讯作者：
Olshansky B