Diversity of CRISPR-Cas immune systems and molecular machines.
Diversity of CRISPR-Cas immune systems and molecular machines.
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DOI：
10.1186/s13059-015-0816-9
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发表时间：
2015-11-09
期刊：
影响因子：
12.3
通讯作者：
Barrangou R
中科院分区：
文献类型：
--
作者：
Barrangou R
细菌获得性免疫取决于CRISPR-Cas系统，该系统提供DNA编码、RNA介导的外源核酸靶向。大量的CRISPR分子机器广泛存在于原核基因组中，具有多种Cas核酸酶，可以重新用于各种应用。
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.