Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome.
Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome.
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DOI：
10.1111/jcpp.12938
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发表时间：
2018-06
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通讯作者：
Vanessa A. Petruo;B. Bodmer;V. Brandt;Leoni Baumung;V. Roessner;A. Münchau;C. Beste
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作者：
Vanessa A. Petruo;B. Bodmer;V. Brandt;Leoni Baumung;V. Roessner;A. Münchau;C. Beste
图雷特吉尔综合征（Gilles de la Tourette Syndrome， GTS）是一种多面性神经精神发育障碍，发病于儿童期或青春期，通常在成年早期缓解。一个新兴的关于该综合征的概念表明，它是一种有目的的行为障碍，其中感觉过程及其与运动反应（动作）的关系起着特别重要的作用。因此，这种综合征可能被认为是“感知-行动结合”改变的一种情况。在当前的研究中，我们在抑制控制的背景下测试了这个新概念。方法对35名青少年GTS患者和39名健康对照者进行Go/ nogo任务测试，以控制触发相同动作的感觉信息的复杂性；即抑制运动反应。这与事件相关电位记录、脑电图数据分解和源定位相结合。结果：与对照组相比，GTS患者表现出更差的表现，与双峰视听刺激相比，单峰视觉抑制控制的表现差异更大。这表明，双峰刺激和反应之间的结合增加，导致在双峰刺激和单峰刺激指示的反应之间切换的成本增加。神经生理学数据表明，这与刺激评价和反应选择之间的中介机制有关；即在右侧顶叶下皮层（BA40）的感知-动作结合过程。结论GTS患者的刺激-动作抑制结合强于健康对照组，并影响抑制控制，证实了GTS可能是知觉-动作整合（结合）改变的一个条件；即有目的的行为的混乱。
BACKGROUND Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions.