Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.
Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.
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保守的伽马疱疹病毒激酶和组蛋白变体 H2AX 促进伽马疱疹病毒在体内的潜伏期。
DOI：
10.1016/j.virol.2010.05.027
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发表时间：
2010
期刊：
影响因子：
3.7
通讯作者：
S. Gauld
中科院分区：
文献类型：
--
作者：
V. Tarakanova;E. Stanitsa;Steven M. Leonardo;T. Bigley;S. Gauld
Many herpesvirus-encoded protein kinases facilitate viral lytic replication. Importantly, the role of viral kinases in herpesvirus latency is less clear. Mouse gammaherpesvirus-68 (MHV68)-encoded protein kinase orf36 facilitates lytic replication in part through activation of the host DNA damage response (DDR). Here we show that MHV68 latency was attenuated in the absence of orf36 expression. Unexpectedly, our study uncovered enzymatic activity-independent role of orf36 in the establishment of MHV68 latency following intraperitoneal route of infection. H2AX, an important DDR protein, facilitates MHV68 lytic replication and may be directly phosphorylated by orf36 during lytic infection. In this study, H2AX deficiency, whether systemic or limited to infected cells, attenuated the establishment of MHV68 latency in vivo. Thus, our work reveals viral kinase-dependent regulation of gammaherpesvirus latency and illuminates a novel link between H2AX, a component of a tumor suppressor DDR network, and in vivo latency of a cancer-associated gammaherpesvirus.
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Kruppel相关的盒子结构域相关蛋白-1作为Kaposi肉瘤相关的疱疹病毒的潜伏期调节剂及其通过病毒蛋白激酶的调节。
影响因子：
11.2
作者：
Chang PC;Fitzgerald LD;Van Geelen A;Izumiya Y;Ellison TJ;Wang DH;Ann DK;Luciw PA;Kung HJ
通讯作者：
Kung HJ
影响因子：
11.2
作者：
Mezhir, JJ;Advani, SJ;Weichselbaum, RR
通讯作者：
Weichselbaum, RR
影响因子：
30.3
作者：
Tarakanova, Vera L.;Leung-Pinecla, Van;Virgin, Herbert W., IV
通讯作者：
Virgin, Herbert W., IV
DOI：
10.1073/pnas.98.4.1895
发表时间：
2001-02
影响因子：
11.1
作者：
D. Wolf;C. T. Courcelle;M. Prichard;E. Mocarski
通讯作者：
D. Wolf;C. T. Courcelle;M. Prichard;E. Mocarski
DOI：
10.1016/j.bbapap.2007.08.009
发表时间：
2008-01-01
影响因子：
3.2
作者：
Gershburg, Edward;Pagano, Joseph S.
通讯作者：
Pagano, Joseph S.