Quantitative MRI in the very preterm brain: Assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging
Quantitative MRI in the very preterm brain: Assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging
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DOI：
10.1016/j.neuroimage.2012.08.086
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发表时间：
2013-01-01
期刊：
影响因子：
5.7
通讯作者：
Sled, John G.
中科院分区：
文献类型：
--
作者：
Nossin-Manor, Revital;Card, Dallas;Sled, John G.
采用磁化传递比（MTR）、弥散张量成像（DTI）参数和T-1弛豫测量值创建表征早产儿（24-32孕周）新生儿大脑组织微观结构的参数图，并在早产儿和足月等效年龄进行扫描。分组图像配准用于确定个体扫描与早产儿和足月期合并参数数据之间的解剖对应关系。这些参数图显示了明显的对比，其相互关系在不同的大脑区域和早产儿和孕期之间有所不同。对于不同的定量参数，观察到离散的区域变化模式，这为MRI对大脑成熟的多个独立方面敏感提供了证据。与早产儿相比，期等值期MTR值的区域变化格局发生了显著变化，信号对比对区域的顺序排序发生了变化。这与所有其他参数不同，这些参数在两个时间点保留了区域排名。从髓鞘形成和结构组织的角度解释数据，我们报告了与现有组织学数据的一致性，并证明了定量MRI在新生儿时期追踪大脑成熟的价值。(C) 2012爱思唯尔公司版权所有。
Magnetization transfer ratio (MTR), diffusion tensor imaging (DTI) parameters and T-1 relaxometry values were used to create parametric maps characterizing the tissue microstructure of the neonatal brain in infants born very premature (24-32 gestational weeks) and scanned at preterm and term equivalent age. Group-wise image registration was used to determine anatomical correspondence between individual scans and the pooled parametric data at the preterm and term ages. These parametric maps showed distinct contrasts whose interrelations varied across brain regions and between the preterm and term period. Discrete patterns of regional variation were observed for the different quantitative parameters, providing evidence that MRI is sensitive to multiple independent aspects of brain maturation. MTR values showed a marked change in the pattern of regional variation at term equivalent age compared to the preterm period such that the ordinal ranking of regions by signal contrast changed. This was unlike all other parameters where the regional ranking was preserved at the two time points. Interpreting the data in terms of myelination and structural organization, we report on the concordance with available histological data and demonstrate the value of quantitative MRI for tracking brain maturation over the neonatal period. (C) 2012 Elsevier Inc. All rights reserved.