Prognostic significance of pre- and postoperative glasgow prognostic score for patients with non-small cell lung cancer.

Prognostic significance of pre- and postoperative glasgow prognostic score for patients with non-small cell lung cancer.
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非小细胞肺癌患者术前和术后格拉斯哥预后评分的预后意义。

DOI：
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发表时间：
2014
期刊：
Anticancer research
影响因子：
2
通讯作者：
Kunihide Nakamura
Kunihide Nakamura
中科院分区：
医学4区
文献类型：
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作者：
M. Tomita;T. Ayabe;Eiichi Chosa;Kunihide Nakamura

文献摘要

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背景 我们先前的研究表明，术前格拉斯哥预后评分(GPS)对非小细胞肺癌(NSCLC)切除患者的预后有影响。在本研究中，还研究了术前GPS1或2的非小细胞肺癌患者术后GPS值与预后的关系。 患者和方法 312名连续接受非小细胞肺癌手术且随访期超过5年的患者入选。GPS值计算如下：C反应蛋白水平升高(&gt；1.0 mg/dl)和低白蛋白血症(&lt；3.5g/dl)的患者被归入GPS2。 结果 GPS0级264例(84.62%)，GPS1级31例(9.94%)，GPS2级17例(5.45%)。48例术前GPS1或2级者，术后GPS值为0者30例，其余18例术后GPS值无明显变化。术后GPS0和1~2的患者5年生存率分别为73.02%和11.11%。 结论 术前GPS可能有助于非小细胞肺癌患者的术后预后。此外，术后持续的高GPS预示着NSCLC患者预后不良。
BACKGROUND Our previous study showed the prognostic impact of preoperative Glasgow prognostic score (GPS) in patients who underwent resection for non-small cell lung cancer (NSCLC). In the present study, the relationship between postoperative GPS and prognosis was also examined in patients with NSCLC with preoperative GPS 1 or 2. PATIENTS AND METHODS Three hundred and twelve consecutive patients resected for NSCLC with a follow-up period of more than five years were enrolled. The GPS was calculated as follows: patients with elevated C-reactive protein level (>1.0 mg/dl) and hypoalbuminemia (<3.5 g/dl) were assigned to GPS 2. Patients with one or no abnormal value were assigned to GPS 1 or GPS 0. RESULTS Study patients were allocated as follows: 264 (84.62%) to GPS 0; 31 (9.94%) to GPS 1; and 17 (5.45%) to GPS 2. The prognosis of the patients with preoperative GPS 2 was significantly poorer. Postoperative GPS was also examined for 48 patients with preoperative GPS 1 or 2. In 30/48 patients, postoperative GPS was improved to GPS 0, however, the postoperative GPS of the remaining 18 patients did not change to GPS 0. The 5-year survival of patients with postoperative GPS 0 and 1-2 were 73.02% and 11.11%, respectively. CONCLUSION Preoperative GPS may be useful for postoperative prognosis of patients with NSCLC. Furthermore, persistently high GPS after surgery indicates poor prognosis in patients with NSCLC.