Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer
Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer
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DOI：
10.1269/jrr.11115
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发表时间：
2012-05-01
影响因子：
2
通讯作者：
Shinohara, Masanori
中科院分区：
文献类型：
--
作者：
Teshima, Keiko;Murakami, Ryuji;Shinohara, Masanori
我们回顾性评估了6例晚期口腔癌患者的腮腺和颌下腺的计算机断层扫描（CT）和组织病理学检查结果之间的关系。入选标准为口腔鳞状细胞癌的病理诊断，术前放化疗（CRT）总剂量为30戈伊，口服S-1（80 mg/m2/d），CRT前和CRT后2周通过CT进行形态学评估和Saxon试验进行功能评估，以及辐照腮腺和颌下腺的组织病理学切片。在组织病理学解释中，将腺体结构分为腺泡细胞、导管细胞和脂肪细胞以及其他组织。采用Mann-Whitney检验和斯皮尔曼秩相关检验确定组织病理学变化。30-戈伊照射后，唾液分泌量、腮腺和下颌下区体积均明显减少（P
We retrospectively evaluated the relationship between computed tomography (CT)- and histopathological findings of parotid and submandibular glands in six patients treated for advanced oral cancer. Eligibility criteria were a pathologic diagnosis of oral squamous cell carcinoma, preoperative chemoradiation therapy (CRT) with a total dose of 30 Gy and oral S-1 (80 mg/m(2)/day), the availability of morphological assessments by CT and of functional assessments with the Saxon test before- and 2 weeks after CRT, and the availability of histopathological slides of irradiated parotid and submandibular glands. In the histopathological interpretation, gland structures were divided into acinar-, duct-, and adipose cells and other tissues. The Mann-Whitney test and the Spearman rank correlation test were used to determine histopathological changes. After 30-Gy irradiation, saliva production and parotid and submandibular volumes were significantly decreased (P