Integrin switching modulates adhesion dynamics and cell migration
Integrin switching modulates adhesion dynamics and cell migration
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DOI：
10.4161/cam.3.2.8036
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发表时间：
2009-04-01
影响因子：
3.2
通讯作者：
Danen, Erik H. J.
中科院分区：
文献类型：
--
作者：
Truong, Hoa;Danen, Erik H. J.
当细胞受到刺激移动时，例如在发育、伤口愈合或血管生成期间，它们会经历细胞-基质粘连周转的变化。这通常伴随着整合素表达谱的改变，整合素是细胞外基质受体，介导这些粘连内的锚定。在这里，我们讨论了结合纤维连接蛋白的两种不同类型的整合素之间的表达变化如何对细胞-基质黏附动力学和细胞运动产生显著影响。
When cells are stimulated to move, for instance during development, wound healing or angiogenesis, they undergo changes in the turnover of their cell-matrix adhesions. This is often accompanied by alterations in the expression profile of integrins-the extracellular matrix receptors that mediate anchorage within these adhesions. Here, we discuss how a shift in expression between two different types of integrins that bind fibronectin can have dramatic consequences for cell-matrix adhesion dynamics and cell motility.