Interhemispheric claustral circuits coordinate sensory and motor cortical areas that regulate exploratory behaviors.
Interhemispheric claustral circuits coordinate sensory and motor cortical areas that regulate exploratory behaviors.
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DOI：
10.3389/fnsys.2014.00093
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发表时间：
2014
影响因子：
3
通讯作者：
Alloway KD
中科院分区：
文献类型：
--
作者：
Smith JB;Alloway KD
屏状核在某些类型的感觉运动信息的半球间传递中起作用。而在大鼠运动（M1）皮质的触须区发送密集的投影到对侧屏状核，M1前肢代表没有。屏状核向M1和S1皮层的须区发出强的同侧投射，但向前肢皮层区的投射较弱。这些区别表明，M1的预测对侧屏状核的功能之一是协调皮质区，调节周边传感器的运动过程中的行为，依赖于双边的感觉采集。如果这一假设是正确的，那么类似的大脑半球间回路应该将额叶眼野（FEF）与对侧屏状核及其投射网络连接到视觉相关的皮层区域。为了验证这一假设，顺行和逆行示踪剂被放置在生理定义的部分FEF和初级视觉皮层（V1）的大鼠。我们观察到密集的FEF预测对侧屏状核终止于中间的屏状核神经元，项目的FEF和V1。虽然到屏状核的FEF输入主要来自对侧半球，但到FEF和V1的屏状核投射主要是同侧的。详细比较目前的结果与我们以前的研究somatomotor claustral电路揭示了一个定义明确的功能地形，其中腹侧屏状核与视觉皮层区和背侧区域与somatomotor区连接。这些结果表明，屏状核内的子区域在协调皮层区域中起着至关重要的作用，这些皮层区域在探索和其他需要感官注意的行为过程中调节特定于模态的感官信息的获取。
The claustrum has a role in the interhemispheric transfer of certain types of sensorimotor information. Whereas the whisker region in rat motor (M1) cortex sends dense projections to the contralateral claustrum, the M1 forelimb representation does not. The claustrum sends strong ipsilateral projections to the whisker regions in M1 and somatosensory (S1) cortex, but its projections to the forelimb cortical areas are weak. These distinctions suggest that one function of the M1 projections to the contralateral claustrum is to coordinate the cortical areas that regulate peripheral sensor movements during behaviors that depend on bilateral sensory acquisition. If this hypothesis is true, then similar interhemispheric circuits should interconnect the frontal eye fields (FEF) with the contralateral claustrum and its network of projections to vision-related cortical areas. To test this hypothesis, anterograde and retrograde tracers were placed in physiologically-defined parts of the FEF and primary visual cortex (V1) in rats. We observed dense FEF projections to the contralateral claustrum that terminated in the midst of claustral neurons that project to both FEF and V1. While the FEF inputs to the claustrum come predominantly from the contralateral hemisphere, the claustral projections to FEF and V1 are primarily ipsilateral. Detailed comparison of the present results with our previous studies on somatomotor claustral circuitry revealed a well-defined functional topography in which the ventral claustrum is connected with visuomotor cortical areas and the dorsal regions are connected with somatomotor areas. These results suggest that subregions within the claustrum play a critical role in coordinating the cortical areas that regulate the acquisition of modality-specific sensory information during exploration and other behaviors that require sensory attention.