Mechanism Mediating Reticuloendothelial System Depression After Surgery 1
Mechanism Mediating Reticuloendothelial System Depression After Surgery 1
复制标题
手术后网状内皮系统抑制的调节机制 1
DOI：
10.3181/00379727-133-34638
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发表时间：
1970
影响因子：
--
通讯作者：
T. Saba
中科院分区：
文献类型：
--
作者：
T. Saba
总结手术诱导了网状内皮系统（RES）的显著和短暂抑制，其特征为胶体碳和凝胶化“RP试验脂肪乳剂”的吞噬清除受损。术后约2.5小时观察到RE恢复，术后3小时和4小时存在RE刺激阶段。循环调理素活性下降，在RE抑郁症手术后，并恢复到控制水平在RE恢复期间。比较吞噬细胞和调理素的测定表明，RE抑郁症手术后是由于调理素活性的降低。这些研究结果支持的概念，增加宿主易感性的疾病手术后可能是介导的调理系统和网状内皮功能的改变。
Summary Surgery induced a significant and transient depression of the reticuloendothelial system (RES) as characterized by the impaired phagocytic clearance of colloidal carbon and the gelatinized “RP test lipid emulsion.” RE recovery was observed at approximately 2.5-hr postsurgery, and a phase of RE stimulation existed by 3- and 4-hr postsurgery. Circulating opsonic activity was decreased during RE depression after surgery, and recovered toward control levels during the period of RE recovery. Comparative phagocytic and opsonic determinations suggested that RE depression after surgery was due to the decrease in opsonin activity. These findings support the concept that the increased host susceptibility to disease after surgery may be mediated in part by an alteration of the opsonic system and reticuloendothelial function.