Hawaiian Volcanic Ash, an Airborne Fomite for Nontuberculous Mycobacteria.
Hawaiian Volcanic Ash, an Airborne Fomite for Nontuberculous Mycobacteria.
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DOI：
10.1029/2023gh000889
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发表时间：
2024-01
期刊：
影响因子：
4.8
通讯作者：
Honda JR
中科院分区：
文献类型：
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作者：
Dawrs SN;Virdi R;Norton GJ;Elias T;Hasan NA;Robinson S;Matriz J;Epperson LE;Glickman CM;Beagle S;Crooks JL;Nelson ST;Chan ED;Damby DE;Strong M;Honda JR
非结核分枝杆菌（NTM）是环境获得的机会致病菌，可导致慢性肺部疾病。在美国，夏威夷显示了NTM肺部感染的最高流行率。在这里，我们调查了在位于夏威夷岛的Kastlauea火山在促进NTM的增长和多样性的活火山作用的潜在作用。我们恢复了已知会导致肺部疾病的NTM，这些疾病来自于从Kamplauea环境中收集的管道生物膜和土壤。我们还发现了活的鸟分枝杆菌、分枝杆菌和胞内分枝杆菌亚种。在2018年Kamplauea火山爆发期间收集的火山灰上的嵌合体。土壤样品的分析表明，NTM流行与磷，硫和总有机碳的体积含量呈正相关。在生长试验中，我们表明磷的利用对于Kamplauea衍生的NTM的增殖是必不可少的，并证明用火山灰培养的NTM粘附在火山灰表面并保持活力。在2018年火山爆发时收集到的环境尘埃中含有大量新鲜的火山玻璃，这表明火山灰在岛屿间传播。使用全基因组测序进行的系统基因组分析显示，Kampillauea衍生的NTM与其他夏威夷群岛上鉴定的呼吸道分离株在遗传上相似。因此，我们认为火山爆发可以在大范围内重新分配环境微生物。虽然还需要进一步的研究来确认火山灰在NTM传播中的直接作用，但我们的研究结果表明，火山颗粒物具有重新分布NTM的能力，因此应该将其作为这些新兴的环境获得性呼吸道感染的污染物进行研究。全球火山爆发从未报告过搭便车传染性病原体的长距离运输从2018年Kampolauea火山爆发中回收的灰烬含有已知会导致肺部疾病的非结核分枝杆菌（NTM）物种基因组评估显示Kampolauea衍生的NTM与其他夏威夷群岛上鉴定的呼吸道分离株在遗传上相似
Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause chronic lung disease. Within the U.S., Hawai'i shows the highest prevalence rates of NTM lung infections. Here, we investigated a potential role for active volcanism at the Kīlauea Volcano located on Hawai'i Island in promoting NTM growth and diversity. We recovered NTM that are known to cause lung disease from plumbing biofilms and soils collected from the Kīlauea environment. We also discovered viable Mycobacterium avium, Mycobacterium abscessus, and Mycobacterium intracellulare subsp. chimaera on volcanic ash collected during the 2018 Kīlauea eruption. Analysis of soil samples showed that NTM prevalence is positively associated with bulk content of phosphorus, sulfur, and total organic carbon. In growth assays, we showed that phosphorus utilization is essential for proliferation of Kīlauea‐derived NTM, and demonstrate that NTM cultured with volcanic ash adhere to ash surfaces and remain viable. Ambient dust collected on O'ahu concurrent with the 2018 eruption contained abundant fresh volcanic glass, suggestive of inter‐island ash transport. Phylogenomic analyses using whole genome sequencing revealed that Kīlauea‐derived NTM are genetically similar to respiratory isolates identified on other Hawaiian Islands. Consequently, we posit that volcanic eruptions could redistribute environmental microorganisms over large scales. While additional studies are needed to confirm a direct role of ash in NTM dispersal, our results suggest that volcanic particulates harbor and can redistribute NTM and should therefore be studied as a fomite for these burgeoning, environmentally acquired respiratory infections. Long‐range transport of hitch‐hiking infectious agents has never been reported for volcanic eruptions globally Ash recovered from the 2018 Kīlauea Volcano eruption harbors species of nontuberculous mycobacteria (NTM) known to cause lung disease Genomic evaluation reveals Kīlauea‐derived NTM are genetically similar to respiratory isolates identified on other Hawaiian Islands