17-hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats
17-hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats
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DOI：
10.1016/j.ajog.2009.05.054
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发表时间：
2009-09-01
影响因子：
9.8
通讯作者：
LaMarca, Babbette
中科院分区：
文献类型：
--
作者：
Veillon, Edward W., Jr.;Keiser, Sharon D.;LaMarca, Babbette
目的：妊娠大鼠子宫胎盘灌注量减少与高血压、细胞因子升高和内皮素(ET-1)系统激活有关我们的目的是确定17-羟孕酮己酮(17-OHP)的抗炎作用是否能减少环磷酰胺刺激的血管活性通路，这些血管活性通路与胎盘缺血相关。研究设计：测定下列妊娠对照组、妊娠对照组加17-羟孕酮(6 mg/kg)、RUPP大鼠的平均动脉压(MAP)、肿瘤坏死因子-α(TNF-α)、白介素6(IL)-6和肾脏ET-1。结果：与妊娠对照组相比，RUPP大鼠的MAP增加了29 mm Hg(P
OBJECTIVE: Reduction in uteroplacental perfusion (RUPP) in pregnant rats is associated with hypertension, elevated cytokines, and activation of the endothelin (ET-1) system Our objective was to determine whether the anti inflammatory properties of 17-alpha-hydroxyprogesterone caproale (17 OHP) reduce cylokine-stimulated vasoactive pathways that are associated with hypertension in response to placental ischemia.STUDY DESIGN: Mean arterial pressure (MAP), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and renal ET-1 were measured in the following pregnant controls, pregnant controls plus 17 OHP (6 6 mg/kg), RUPP rats, and RUPP rats plus 17 OHPRESULTS: MAP increased 29 mm Hg in RUPP rats compared with pregnant controls (P