Seroepidemiology of melioidosis in children from a remote region of Papua New Guinea
Seroepidemiology of melioidosis in children from a remote region of Papua New Guinea
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DOI：
10.1093/inthealth/ihu088
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发表时间：
2015-09-01
影响因子：
2.5
通讯作者：
Warner, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Diefenbach-Elstob, Tanya R.;Graves, Patricia M.;Warner, Jeffrey M.
巴布亚新几内亚的Balimo地区以前被确定为多发于儿童的类鼻疽地方病。在卫生资源稀缺的地方，血清流行病学可用于评估类鼻疽伯克霍尔德氏菌的暴露，从而获得类鼻疽的风险。Logistic回归用于确定间接血凝试验（IHA）血清反应性与环境和人口统计学/文化因素之间的关联，以帮助确定与接触B相关的风险因素。在968名参与者中，92.9%（899/968）是儿童，代表了邻近Balimo地区社区学校人口的大多数。其中24.6%（221/899）为血清学阳性。在泻湖中洗澡（OR=2.679），从井或泻湖中饮水（OR=1.474），是Siboko（OR=1.914）或Wagumisi（OR=1.942）氏族的成员与血清阳性显着相关。在多变量分析中，饮用水从井或泻湖（OR=1.713），和Siboko（OR=2.341）和Wabadala（OR=2.022）氏族与seropositivity.This儿童研究支持的意见，在该地区与地下水的相互作用是获得类鼻疽的危险因素。旨在限制这种接触的公共卫生措施可能有助于降低这个偏远社区患类鼻疽的风险。与氏族结构的联系可能会提供更具体的文化见解，但这需要进一步阐明。
The Balimo region in Papua New Guinea has previously been identified as melioidosis-endemic with a predilection for children. Where health resources are scarce, seroepidemiology can be used to assess exposure to Burkholderia pseudomallei and therefore risk of acquiring melioidosis.Logistic regression was used to determine associations between indirect haemagglutination assay (IHA) seroreactivity with environmental and demographic/cultural factors to aid in determining risk factors associated with exposure to B. pseudomallei in children.Of the 968 participants, 92.9% (899/968) were children, representing the majority of the community school population in the immediate Balimo region. Of these, 24.6% (221/899) were seropositive. Bathing in the lagoon (OR=2.679), drinking from the well or lagoon (OR=1.474), and being a member of the Siboko (OR=1.914) or Wagumisi (OR=1.942) clans were significantly associated with seropositivity. In the multivariate analysis, drinking from a well or lagoon (OR=1.713), and the Siboko (OR=2.341) and Wabadala (OR=2.022) clans were associated with seropositivity.This study in children supports observations that interactions with groundwater in this region are risk factors in acquiring melioidosis. Public health measures intended to limit this exposure may help reduce the risk of acquiring melioidosis in this remote community. Associations with clan structure may provide more cultural specific insights, however this requires further elucidation.