Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain.
Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain.
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DOI：
10.1136/bmjopen-2020-042887
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发表时间：
2021-05-05
期刊：
影响因子：
2.9
通讯作者：
Smith BH
中科院分区：
文献类型：
--
作者：
Hébert HL;Veluchamy A;Baskozos G;Fardo F;Van Ryckeghem DML;Pascal MMV;Jones C;Milburn K;Pearson ER;Crombez G;Bennett DLH;Meng W;Palmer CNA;Smith BH
神经性疼痛是一种常见的躯体感觉系统疾病，影响7%-10%的普通人群。这种疾病给患者和医疗服务带来了巨大的社会和经济负担。然而，并不是每个有相关潜在病因的人都会出现相应的疼痛。DOLORisk邓迪是一个由欧盟资助的队列，是多中心DOLORisk联盟的一部分，其建立旨在增加目前对这种发病变化的理解。特别是，该队列将允许探索神经性疼痛发作的社会心理、临床和遗传预测因子。DOLORisk邓迪是通过使用标准化的“核心”研究方案对两个预先存在的苏格兰人群队列进行神经性疼痛的再表型分析而构建的：苏格兰泰赛德地区糖尿病遗传学审核和研究（GoDARTS）（n=5236），主要由来自泰赛德地区的2型糖尿病患者组成，以及苏格兰世代：苏格兰家庭健康研究（GS：SFHS; n=20 221）。再表型分两个阶段进行：基线邮政调查和结合邮政和在线随访调查。DOLORisk邓迪由9155名参与者（GoDARTS=1915; GS：SFHS=7240）组成，他们对基线调查进行了回复，其中6338名（69.2%; GoDARTS=1046; GS：SFHS=5292）还对随访调查（18个月后）进行了回复。基线时，GoDARTS中慢性神经性疼痛（Doubletree Neuropathique en 4 Questions问卷评分≥3，持续时间≥3个月）的患者比例为30.5%，Generation Scotland中为14.2%。电子记录连接使大规模的遗传关联研究得以进行，神经性疼痛的风险模型已经构建。该队列由一个访问委员会维护，通过该委员会鼓励合作。关于如何做到这一点的详细情况将在研究网站上公布（http：//dolorisk.eu/）。计划对这一组进行进一步的后续调查，并正在为此准备资金申请。这将与UK Biobank的类似疼痛再表型分型协调进行。
Neuropathic pain is a common disorder of the somatosensory system that affects 7%–10% of the general population. The disorder places a large social and economic burden on patients as well as healthcare services. However, not everyone with a relevant underlying aetiology develops corresponding pain. DOLORisk Dundee, a European Union-funded cohort, part of the multicentre DOLORisk consortium, was set up to increase current understanding of this variation in onset. In particular, the cohort will allow exploration of psychosocial, clinical and genetic predictors of neuropathic pain onset. DOLORisk Dundee has been constructed by rephenotyping two pre-existing Scottish population cohorts for neuropathic pain using a standardised ‘core’ study protocol: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) (n=5236) consisting of predominantly type 2 diabetics from the Tayside region, and Generation Scotland: Scottish Family Health Study (GS:SFHS; n=20 221). Rephenotyping was conducted in two phases: a baseline postal survey and a combined postal and online follow-up survey. DOLORisk Dundee consists of 9155 participants (GoDARTS=1915; GS:SFHS=7240) who responded to the baseline survey, of which 6338 (69.2%; GoDARTS=1046; GS:SFHS=5292) also responded to the follow-up survey (18 months later). At baseline, the proportion of those with chronic neuropathic pain (Douleur Neuropathique en 4 Questions questionnaire score ≥3, duration ≥3 months) was 30.5% in GoDARTS and 14.2% in Generation Scotland. Electronic record linkage enables large scale genetic association studies to be conducted and risk models have been constructed for neuropathic pain. The cohort is being maintained by an access committee, through which collaborations are encouraged. Details of how to do this will be available on the study website (http://dolorisk.eu/). Further follow-up surveys of the cohort are planned and funding applications are being prepared to this effect. This will be conducted in harmony with similar pain rephenotyping of UK Biobank.
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影响因子：
30.8
作者：
Mahajan A;Taliun D;Thurner M;Robertson NR;Torres JM;Rayner NW;Payne AJ;Steinthorsdottir V;Scott RA;Grarup N;Cook JP;Schmidt EM;Wuttke M;Sarnowski C;Mägi R;Nano J;Gieger C;Trompet S;Lecoeur C;Preuss MH;Prins BP;Guo X;Bielak LF;Below JE;Bowden DW;Chambers JC;Kim YJ;Ng MCY;Petty LE;Sim X;Zhang W;Bennett AJ;Bork-Jensen J;Brummett CM;Canouil M;Ec Kardt KU;Fischer K;Kardia SLR;Kronenberg F;Läll K;Liu CT;Locke AE;Luan J;Ntalla I;Nylander V;Schönherr S;Schurmann C;Yengo L;Bottinger EP;Brandslund I;Christensen C;Dedoussis G;Florez JC;Ford I;Franco OH;Frayling TM;Giedraitis V;Hackinger S;Hattersley AT;Herder C;Ikram MA;Ingelsson M;Jørgensen ME;Jørgensen T;Kriebel J;Kuusisto J;Ligthart S;Lindgren CM;Linneberg A;Lyssenko V;Mamakou V;Meitinger T;Mohlke KL;Morris AD;Nadkarni G;Pankow JS;Peters A;Sattar N;Stančáková A;Strauch K;Taylor KD;Thorand B;Thorleifsson G;Thorsteinsdottir U;Tuomilehto J;Witte DR;Dupuis J;Peyser PA;Zeggini E;Loos RJF;Froguel P;Ingelsson E;Lind L;Groop L;Laakso M;Collins FS;Jukema JW;Palmer CNA;Grallert H;Metspalu A;Dehghan A;Köttgen A;Abecasis GR;Meigs JB;Rotter JI;Marchini J;Pedersen O;Hansen T;Langenberg C;Wareham NJ;Stefansson K;Gloyn AL;Morris AP;Boehnke M;McCarthy MI
通讯作者：
McCarthy MI
影响因子：
7.4
作者：
Montes, Antonio;Roca, Gisela;Sabate, Sergi
通讯作者：
Sabate, Sergi
影响因子：
7.4
作者：
Torrance N;Lawson KD;Afolabi E;Bennett MI;Serpell MG;Dunn KM;Smith BH
通讯作者：
Smith BH
影响因子：
15.8
作者：
McIntosh, Andrew M.;Hall, Lynsey S.;Hocking, Lynne J.
通讯作者：
Hocking, Lynne J.
影响因子：
7.7
作者：
Smith, Blair H.;Campbell, Archie;Morris, Andrew D.
通讯作者：
Morris, Andrew D.