Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat
Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat
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DOI：
10.1152/ajpgi.1999.276.4.g951
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发表时间：
1999-04-01
影响因子：
4.5
通讯作者：
Gall, DG
中科院分区：
文献类型：
--
作者：
Meddings, JB;Jarand, J;Gall, DG
BB（可能原文是BB大鼠，误写成BE）大鼠会自发产生自身免疫性糖尿病。给这些动物喂食水解酪蛋白饮食可显著降低该疾病的发病率，这表明一种饮食抗原参与了这种疾病的发病机制。在其他与肠腔抗原相关的综合征中，包括乳糜泻和克罗恩病，肠道通透性增加被认为在病因学上起作用。因此，本研究的目的是评估在疾病发生前BB大鼠是否也存在通透性增加的情况。通过测量胃肠道通透性，我们发现，在正常饮食或水解酪蛋白饮食的动物中，在胰岛炎和临床糖尿病发生之前，胃和小肠通透性就已经增加。尽管饮食蛋白的水解显著降低了糖尿病的发病率，但它并没有改变小肠通透性异常，这表明这是一个早期事件。通透性增加似乎在几种免疫性疾病的发生中起早期作用，并且可能是这些疾病中的一个常见事件。
The BE rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, suggesting that a dietary antigen is involved in the pathogenesis of this disease. In other syndromes associated with luminal antigens, including celiac and Crohn's disease, increased intestinal permeability has been suggested to play an etiological role. Therefore, the objective of this study was to evaluate whether increased permeability was also present in BE rats before disease development. By measuring gastrointestinal permeability, in animals on a regular or hydrolyzed casein diet, we were able to demonstrate that increased gastric and small intestinal permeability appeared before the development of both insulitis and clinical diabetes. Although hydrolysis of dietary protein significantly reduced the incidence of diabetes, it did not alter the small intestinal permeability abnormality, suggesting that this is an early event. Increased permeability appears to have an early role in the genesis of several immunological diseases and may represent a common event in these diseases.