Skeletal muscle oxidative capacity in young and older women and men
Skeletal muscle oxidative capacity in young and older women and men
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DOI：
10.1152/jappl.2000.89.3.1072
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Ng, AV
中科院分区：
文献类型：
--
作者：
Kent-Braun, JA;Ng, AV
已经表明骨骼肌氧化能力的下降是人类衰老的一般后果。然而，以前的研究并不总是控制不同水平的体力活动对肌肉氧化能力的影响。为了检验这一假设，即当与可比较的习惯性体力活动水平相匹配时，运动肌肉的氧化能力不会出现与年龄相关的下降，比较了年轻人[n = 19; 33.8 +/- 4.8（SD）yr]和老年人[n = 18; 75.5 +/- 4.5岁]的健康女性和男性相似，相对较低的活动水平。肌内代谢的测量是通过使用磷磁共振波谱学完成的。结果表明，运动后磷酸肌酸恢复时间无年龄效应。从而支持所述假设。这些数据表明，骨骼肌氧化能力没有必要的下降，随着人类的衰老，至少通过第七个十年。
It has been suggested that a decline in skeletal muscle oxidative capacity is a general consequence of aging in humans. However, previous studies have not always controlled for the effects of varying levels of physical activity on muscle oxidative capacity. To test the hypothesis that, when matched for comparable habitual physical activity levels, there would be no age-related decline in the oxidative capacity of a locomotor muscle, the postexercise recovery time of phosphocreatine was compared in the tibialis anterior muscle of young [n = 19; 33.8 +/- 4.8 (SD) yr] and older [n = 18; 75.5 +/- 4.5 yr] healthy women and men of similar, relatively low, activity levels. The intramuscular metabolic measurements were accomplished by using phosphorus magnetic resonance spectroscopy. The results indicate that there was no age effect on the postexercise recovery time of phosphocreatine recovery. thus supporting the stated hypothesis. These data suggest that there is no requisite decline in skeletal muscle oxidative capacity with aging in humans, at least through the seventh decade.