Clinical value of decreased superoxide dismutase 1 in patients with epilepsy
Clinical value of decreased superoxide dismutase 1 in patients with epilepsy
复制标题
超氧化物歧化酶1降低在癫痫患者中的临床价值
DOI：
10.1016/j.seizure.2012.05.003
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发表时间：
2012-09-01
影响因子：
3
通讯作者：
Wang, Xuefeng
中科院分区：
文献类型：
--
作者：
Chen, Dan;Lu, Yang;Wang, Xuefeng
目的：我们先前的研究通过蛋白质组学分析发现，癫痫患者脑脊液中超氧化物歧化酶1 （SOD1）明显降低。然而，CSF-SOD1改变与癫痫病理生理的相关性目前尚不清楚。本研究旨在通过测量顽固性癫痫和非顽固性癫痫患者脑脊液中SOD1水平来增加我们对这一问题的理解。方法：共招募52例癫痫患者。29例无耐药性，23例耐药。20名没有任何神经系统疾病证据的个体作为对照。采用酶联免疫吸附法测定脑脊液和血清SOD1浓度。结果：与对照组（0.40 +/- 0.35 ng/ml）相比，耐药组（0.13 +/- 0.12 ng/ml）和非耐药癫痫亚组（0.29 +/- 0.23 ng/ml） CSF-SOD1浓度均降低。耐药组SOD1明显低于非耐药组（P < 0.05）。结论：癫痫患者脑脊液中SOD1水平明显降低，尤其是难治性癫痫患者。低CSF-SOD1水平可能是癫痫患者抗癫痫药物耐药的一个预测指标。(c) 2012英国癫痫协会。Elsevier Ltd.出版。版权所有。
Purpose: Our previous study using proteomic analysis showed that superoxide dismutase 1 (SOD1) was significantly decreased in cerebrospinal fluid (CSF) of patients with epilepsy. However, the relevance of CSF-SOD1 alterations for the pathophysiology of epilepsy is currently unknown. The present study was intended to add to our understanding of this issue by measuring SOD1 levels in the CSF of patients with resistant epilepsy and non-resistant epilepsy.Methods: A total of 52 patients with epilepsy were recruited. 29 were non-resistant, 23 drug-resistant. 20 individuals with no evidence of any neurological diseases were used as control. The concentration of CSF and serum SOD1 was measured by enzyme-linked immunosorbent assay.Results: The concentration of CSF-SOD1 was decreased in both the drug-resistant (0.13 +/- 0.12 ng/ml) and the non-resistant epilepsy subgroups (0.29 +/- 0.23 ng/ml) compared to the control group (0.40 +/- 0.35 ng/ml). SOD1 was significantly lower in the drug-resistant than the non-resistant epilepsy subgroup (P < 0.05).Conclusion: SOD1 levels are decreased in the CSF of patients with epilepsy, especially of patients with intractable epilepsy. Low CSF-SOD1 levels may be a predictor of antiepileptic drug resistance in patients with epilepsy. (c) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.