Comparison of prognostic genomic predictors in colorectal cancer.
Comparison of prognostic genomic predictors in colorectal cancer.
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DOI：
10.1371/journal.pone.0060778
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee JS
中科院分区：
文献类型：
--
作者：
Park YY;Lee SS;Lim JY;Kim SC;Kim SB;Sohn BH;Chu IS;Oh SC;Park ES;Jeong W;Kim SS;Kopetz S;Lee JS
尽管已经从独立研究中确定了几个预后基因组预测因子，但尚不清楚这些预测因子是否与它们对个体患者的预测相一致，以及哪种预测因子表现最好。我们比较了五种预后基因组预测因子，V7RHS, ColoGuideEx, Meta163， OncoDX和MDA114，在预测两个独立的结直肠癌患者的无病生存方面。使用原始分类算法，我们在两个结直肠癌患者队列（n = 229和n = 168）中测试了五种基因组预测因子对无病生存的预测，并评估了预测因子在预测个体患者预后方面的一致性。我们发现，在2个独立队列中，只有两个预测因子OncoDX和MDA114在识别预后不良患者方面表现出强劲的表现。这两种预测因子在预测结果上也有适度但显著的一致性（r < 0.3， P<0.001）。进一步验证已开发的基因组预测因子是必要的。尽管OncoDX和MDA114共享的基因数量有限，但这两种预测因子预测的个体患者预后显著一致。
Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant.
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