Participation in pediatric oncology research protocols: Racial/ethnic, language and age-based disparities
Participation in pediatric oncology research protocols: Racial/ethnic, language and age-based disparities
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DOI：
10.1002/pbc.25472
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发表时间：
2015-08-01
影响因子：
3.2
通讯作者：
Martinez, Maria E.
中科院分区：
文献类型：
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作者：
Aristizabal, Paula;Singer, Jenelle;Martinez, Maria E.
背景儿科肿瘤的生存率有了显著提高，部分原因是患者参与了临床试验。尽管在成人中报告了临床试验参与中的种族/民族不平等，但通过社会人口统计学特征比较参与率的儿科数据和研究很少。本研究的目的是通过年龄、性别、种族/民族、父母语言、癌症类型和保险状况来评估儿童癌症研究方案参与的差异。或治疗方案收集并分析了2008年以来新诊断的儿科癌症患者，2012年在拉迪儿童医院。结果在353例纳入分析，304（86.1%）参加了任何协议。生物标本和治疗方案的入组率分别为84.2%（261/310）和81.1%（206/254）。Logistic回归分析显示，与非西班牙裔白人相比，西班牙裔白人在任何方案中的入组率均显著偏低（81% vs. 91%;比值比[OR]，0.43; 95%置信区间[CI]，0.21-0.90; P=0.021），以及在讲西班牙语与讲英语父母的儿童中（78% vs. 89%; OR，0.45; 95%CI，0.23-0.87; P=0.016）。与0-4岁患者相比，15-21岁患者的代表性明显不足（92% vs.72%; OR，0.21; 95%CI，0.09-0.48; P
BackgroundSurvival rates in pediatric oncology have improved dramatically, in part due to high patient participation in clinical trials. Although racial/ethnic inequalities in clinical trial participation have been reported in adults, pediatric data and studies comparing participation rates by socio-demographic characteristics are scarce. The goal of this study was to assess differences in research protocol participation for childhood cancer by age, sex, race/ethnicity, parental language, cancer type, and insurance status.ProcedureData on enrollment in any protocol, biospecimen, or therapeutic protocols were collected and analyzed for newly diagnosed pediatric patients with cancer from 2008-2012 at Rady Children's Hospital.ResultsAmong the 353 patients included in the analysis, 304 (86.1%) were enrolled in any protocol. Enrollment in biospecimen and therapeutic protocols was 84.2% (261/310) and 81.1% (206/254), respectively. Logistic regression analyzes revealed significant enrollment underrepresentation in any protocol for Hispanics compared to Non-Hispanic whites (81% vs. 91%; Odds Ratio [OR], 0.43; 95% Confidence Interval [CI], 0.21-0.90; P=0.021) and among children of Spanish-speaking vs. English-speaking parents (78% vs. 89%; OR, 0.45; 95%CI, 0.23-0.87; P=0.016). Compared to patients aged 0-4 years, significant underrepresentation was also found among patients 15-21 years old (92% vs.72%; OR, 0.21; 95% CI, 0.09-0.48; P