The multiple facets of toll-like receptors in transplantation biology.
The multiple facets of toll-like receptors in transplantation biology.
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DOI：
10.1097/tp.0b013e31817c11e6
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发表时间：
2008-07-15
期刊：
影响因子：
6.2
通讯作者：
Goldman M
中科院分区：
文献类型：
--
作者：
Alegre ML;Leemans J;Le Moine A;Florquin S;De Wilde V;Chong A;Goldman M
Toll样受体（TLR）属于微生物产物和应激细胞释放的内源性分子的模式识别受体家族。实验研究表明，TLR参与了急性同种异体移植排斥反应的发生过程，其激活可阻止移植耐受。本文就移植器官中不同类型细胞包括APC、T和B淋巴细胞、上皮细胞和内皮细胞中TLR的表达及其信号传导的影响进行综述。然后，我们讨论了TLR参与排斥现象的不同阶段和TLR介导的事件对抑制同种免疫反应的调节回路的影响。
Toll-like receptors (TLRs) belong to a family of pattern-recognition receptors for microbial products and endogenous molecules released by stressed cells. Experimental studies show that TLRs are involved in the process of acute allograft rejection and that their activation can prevent transplantation tolerance. Herein, we review the expression of TLRs and the impact of TLR signaling in different cell types in grafted organs including APCs, T and B lymphocytes, epithelial and endothelial cells. We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses.