Scapular brown fat removal enhances development of adiposity in cold-exposed obese Zucker rats.
Scapular brown fat removal enhances development of adiposity in cold-exposed obese Zucker rats.
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肩胛骨棕色脂肪的去除促进了寒冷暴露的肥胖 Zucker 大鼠的肥胖发展。
DOI：
10.1152/ajpregu.1984.247.5.r918
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Horwitz,BA
中科院分区：
文献类型：
--
作者：
Stern,JS;Inokuchi,T;Castonguay,TW;Wickler,SJ;Horwitz,BA
为了研究棕色脂肪（BAT）对遗传性肥胖Zucker大鼠（fa/fa）中肥胖发展的贡献，从肥胖和瘦的4周龄雌性动物中去除肩胛棕色脂肪（SBAT）。术后8周，SBAT无再生长。当大鼠被饲养在25 ℃时，脂肪切除术对体重增加、食物摄入和身体组成没有影响。瘦大鼠通过增加BAT质量、蛋白质、细胞结构和腋窝、肾周和胸部仓库中柠檬酸合酶（CS）的活性完全补偿脂肪切除术。β-羟酰辅酶A脱氢酶（HOAD）活性增加，但补偿不完全。在脂肪切除的肥胖大鼠中，只有BAT蛋白和细胞数量增加到足以完全补偿。在第二个实验中，从肥胖和瘦大鼠中取出SBAT，但将大鼠置于寒冷（10摄氏度）中8周。在瘦大鼠中，虽然补偿是不完全的，但足以维持与假手术瘦大鼠相当的体重增加和身体组成。在肥胖大鼠中，脂肪切除术几乎没有或没有补偿，体重增加和脂肪沉积大于假手术肥胖对照组。这些数据支持这样的假设，即减少功能性BAT的量有助于增加肥胖的发展。
To investigate the contribution of brown fat (BAT) to the development of obesity in genetically obese Zucker rats (fa/fa), scapular brown fat (SBAT) was removed from obese and lean 4-wk-old females. Eight weeks after surgery there was no regrowth of SBAT. Lipectomy had no effect on body weight gain, food intake, and body composition when rats were housed at 25 degrees C. Lean rats completely compensated for the lipectomy by increasing BAT mass, protein, cellularity, and activity of citrate synthase (CS) in axillary, perirenal, and thoracic depots. beta-Hydroxyacyl-coenzyme A dehydrogenase (HOAD) activity was increased, but compensation was incomplete. In lipectomized obese rats, only BAT protein and cell number were increased sufficiently for complete compensation. In a second experiment SBAT was removed from obese and lean rats, but rats were housed in the cold (10 degrees C) for 8 wk. In lean rats, although compensation was incomplete, it was sufficient to maintain a weight gain and body composition comparable with sham-operated lean rats. In obese rats, where there was little or no compensation for lipectomy, weight gain and fat deposition were greater than observed in sham-operated obese controls. These data support the hypothesis that reducing the amount of functional BAT contributes to the development of increased adiposity.