Suppression of aflatoxin B-1- or methyl methanesulfonate-induced chromosome aberrations in rat bone marrow cells after treatment with S-methyl methanethiosulfonate
Suppression of aflatoxin B-1- or methyl methanesulfonate-induced chromosome aberrations in rat bone marrow cells after treatment with S-methyl methanethiosulfonate
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DOI：
10.1016/s1383-5718(97)00116-2
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发表时间：
1997-10-24
影响因子：
1.9
通讯作者：
Nakamura, Y
中科院分区：
文献类型：
--
作者：
Ito, Y;Nakamura, Y;Nakamura, Y
研究了s -甲乙硫代磺酸甲酯（MMTS）对黄曲霉毒素B-1 (AFB(1))-或甲磺酸甲酯（MMS）诱导的抑制作用。MMTS显著抑制AFB(1)（间接作用致癌物）和MMS（直接作用致癌物）诱导的CA。在AFB(1)或MMS处理后的所有时期（6、12、18、24和48小时）以及所有剂量的AFB(1)（5、10和20 mg/kg）或MMS（50、75和100 mg/kg）均观察到抑制。在AFB(1)注射前2 h和注射后6 h给予MMTS可有效抑制AFB(1)诱导的CA。MMTS在1 ~ 20 mg/kg体重范围内对AFB(1)诱导的CA的抑制作用与MMTS剂量平行。在MMS注射前2 h和后2 h给予MMTS，可有效抑制MMS诱导的CA。MMTS在1 ~ 15mg /kg体重范围内对mms诱导的CA的抑制作用与MMTS剂量平行。二苯基二硫可以修饰蛋白质如MMTS中的- sh基团，也可以显著抑制AFB(1)-和mms诱导的CA。尽管不排除其他机制，但MMTS对致癌物质诱导的CA的抑制可能是由于MMTS修饰蛋白质中的- sh基团的能力。白菜和洋葱汁中含有大量的MMTS和s -甲基- l-半胱氨酸砜（MMTS的前体），也能显著抑制AFB(1)-或MMTS诱导的CA。这些结果表明MMTS可能是一种化学防癌剂。(C) 1997爱思唯尔科学有限公司
The suppressive effect of S-methyl methanethiosulfonate (MMTS) on aflatoxin B-1 (AFB(1))- or methyl methanesulfonate (MMS)-induced was studied. MMTS significantly suppressed CA induced by both AFB(1) (an indirect-acting carcinogen) and MMS (a direct-acting carcinogen). Suppression was observed at all periods (6, 12, 18, 24 and 48 h) after AFB(1) or MMS treatment and in all doses of AFB(1) (5, 10 and 20 mg/kg) or MMS (50, 75 and 100 mg/kg) investigated. AFB(1)-induced CA was potently suppressed by MMTS given between 2 h before and 6 h after the AFB(1) injection. The suppression of AFB(1)-induced CA by MMTS paralleled the dose of MMTS when MMTS was given in a dose range of 1-20 mg/kg body weight. MMS-induced CA was potently suppressed by MMTS given between 2-h before and 2 h after the MMS injection. The suppressive effect of MMTS on MMS-induced CA paralleled the dose of MMTS when MMTS was given in a dose range of 1-15 mg/kg body weight. Diphenyl disulfide, which modifies -SH groups in proteins like MMTS, also significantly suppressed both AFB(1)- and MMS-induced CA. Although other mechanisms are not excluded, the suppression of carcinogen-induced CA by MMTS may result from the ability of MMTS to modify -SH groups in proteins. The juices of cabbage and onion, which contain considerable amounts of MMTS and S-methyl-L-cysteinesulfoxide (the precursor of MMTS), also significantly suppressed AFB(1)- or MMS-induced CA. These results suggest that MMTS is a possible chemopreventive agent against cancer. (C) 1997 Elsevier Science B.V.