Thalamic network under wakefulness after sleep onset and its coupling with daytime fatigue in insomnia disorder: An EEG-fMRI study
Thalamic network under wakefulness after sleep onset and its coupling with daytime fatigue in insomnia disorder: An EEG-fMRI study
复制标题
失眠症患者入睡后觉醒状态下的丘脑网络及其与白天疲劳的耦合：一项EEG-fMRI研究
DOI：
10.1016/j.jad.2023.04.100
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发表时间：
2023-05-06
影响因子：
6.6
通讯作者：
Sun, Hongqiang
中科院分区：
文献类型：
--
作者：
Guo, Yupeng;Chen, Yun;Sun, Hongqiang
Background: Fatigue is the most common daytime impairment of insomnia disorder (ID). Thalamus is acknowledged as the key brain region closely associated with fatigue. However, the thalamus-based neurobio-logical mechanisms of fatigue in patients with ID remain unknown.Methods: Forty-two ID patients and twenty-eight well-matched healthy controls (HCs) underwent simultaneous electroencephalography--functional magnetic resonance imaging. We calculated the functional connectivity (FC) between the thalamic seed and each voxel across the whole brain in two conditions of wakefulness--after sleep onset (WASO) and before sleep onset. A linear mixed effect model was used to determine the condition effect of the thalamic FC. The correlation between daytime fatigue and the thalamic connectivity was explored.Results: After sleep onset, the connectivity with the bilateral thalamus was increased in the cerebellar and cortical regions. Compared with HCs, ID patients showed significantly lower FC between left thalamus and left cere-bellum under the WASO condition. Furthermore, thalamic connectivity with cerebellum under the WASO con-dition was negatively correlated with Fatigue Severity Scale scores in the pooled sample.Conclusions: These findings contribute to an emerging framework that reveals the link between insomnia-related daytime fatigue and the altered thalamic network after sleep onset, further highlighting the possibility that this neural pathway is a therapeutic target for meaningfully mitigating fatigue.
