New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
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DOI：
10.2174/1573399811309020005
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发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Kensler, Thomas W.
中科院分区：
文献类型：
--
作者：
Chartoumpekis, Dionysios V.;Kensler, Thomas W.
核红细胞因子2样2（Nrf 2）已被描述为转录因子，其充当对外源性和内源性氧化和亲电子应激的适应性反应的主调节剂。Nrf 2与其他分子途径的串扰的证据正在增加;最近的出版物提出了Nrf 2在肥胖症的发展中的作用，以及通过与代谢调控中涉及的其他转录因子和受体的相互作用在脂肪细胞分化的高度调节过程中的作用。在本综述中，我们讨论了现有的数据Nrf 2在肥胖和代谢综合征中的可能作用，以及在临床环境中使用Nrf 2作为治疗靶点的可行性。
Nuclear erythroid factor 2 like 2 (Nrf2) has been described as a transcription factor that serves as a master regulator of the adaptive response to exogenous and endogenous oxidative and electrophilic stresses. Evidence of Nrf2 crosstalk with other molecular pathways is increasing; recent publications have proposed a role of Nrf2 in the development of obesity and in the highly regulated process of adipocyte differentiation through its interaction with other transcription factors and receptors implicated in metabolic regulation. In the present review, we discuss the available data on the possible role of Nrf2 in obesity and metabolic syndrome and the feasibility of using Nrf2 as a therapeutic target in the clinical setting.